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Pic
(Protein involved in intestinal colonization) |
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Produced by Shigella flexneri, EAEC and UPEC. Belongs to the SPATEs (serine protease autotransporters of Enterobacteriaceae) subfamily, noncytotoxic (class 2) SPATE. The pic gene overlaps two other virulence genes, set1A and set1B. ... |
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SigA
(Shigella IgA-like protease homology) |
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Belongs to the SPATEs (serine protease autotransporters of Enterobacteriaceae) subfamily, cytotoxic SPATE. Carried on the she pathogenicity island of Shigella flexneri 2a. ... |
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CT
(Cholera toxin) |
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Genes encoded for CT located on the CTXΦ lysogenic filamentous phage. CT is secreted by Eps (for extracellular protein secretion) system, a type II secretion system, very efficiently into the surrounding milieu. El Tor strain N16961 carries only a single copy of the cholera toxin prophage, other V. cholerae strains may carry several copies. Retrograde transport to the ER occurs mainly via a coat protein COPI-independent pathway. ... |
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| Invasin |
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Homolog of Intimin, a major adhesin of EPEC and EHEC, belongs to inverse autotransporter family (Type Ve). Invasin is expressed in pathogenic Y.enterocolitica strains and Y.pseudotuberculosis, but the Y.pestis inv gene is inactivated by an insertion sequence. The inv gene is located in the middle of a gene cluster encoding the flagella proteins. ~100 kDa, anchored by its amino-terminal region. Invasin has a 100-fold greater affinity for β1-containing integrins than their natural ligand, fibronectin. ... |
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Invasin B/Ifp
(Intimin family protein) |
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InvA-like autotransporter mediating adhesion to host cells and promote colonization of different host tissues. ... |
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Invasin C/Ilp
(Intimin/InvA-like protein) |
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InvA-like autotransporter mediating adhesion to host cells and promote colonization of different host tissues. ... |
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| Invasin D |
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The first member of the invasin family of adhesins with an adhesion domain that adopts an Ig-related fold. ... |
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YadA
( Yersinia adherence protein A) |
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The trimeric autotransporter adhesin Yersinia adhesin A is the prototype of the type Vc secretion system. Present in the virulence plasmids of Y. enterocolitica and Y. pseudotuberculosis. The yadA gene of Y. pestis is inactivated by frameshift. Homotrimeric protein belongs to the family of lollipop-shaped adhesins, with a globular head domain, a rigid stalk domain and a C-teriminal membrane anchor. ... |
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| YapC |
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A homologue of TibA, an adhesin/invasin ETEC. Surface protein may mediate adherence, autoaggregation and biofilm formation. ... |
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| YapE |
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YapE requires proteolytic cleavage by the omptin Pla (plasminogen activator protease). Y. pestis YapE is required to mediate bacterial aggregation and adherence to eukaryotic cells. ... |
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