Offensive virulence factors
1) Adherence
2) Invasion
3) Toxin
3.1) Toxin: membrane-acting
3.2) Toxin: membrane-damaging
3.2.1) Toxin: membrane-damaging: pore-forming
3.2.1.1) Toxin: membrane-damaging: pore-forming: channel-forming involving beta-sheet-containing toxin
3.2.1.2) Toxin: membrane-damaging: pore-forming: channel-forming involving alpha-helix-containing toxin
3.2.1.3) Toxin: membrane-damaging: pore-forming: thiol-activated cholesterol-binding cytolysin
3.2.1.4) Toxin: membrane-damaging: pore-forming: RTX toxin
3.3) Toxin: intracellular toxin
3.3.1) Toxin: intracellular toxin: ADP-ribosyltransferase
3.3.2) Toxin: intracellular toxin: Adenylate cyclase
3.3.3) Toxin: intracellular toxin: Deamidase
3.3.4) Toxin: intracellular toxin: Guanylate cyclase
3.3.5) Toxin: intracellular toxin: N-glycosidase
3.3.6) Toxin: intracellular toxin: DnaseI
4) Actin-based motility
5) Secretion system
5.1) Type III secretion system
5.2) Type IV secretion system
5.3) Autotransporter (Type V)
5.4) Type VI secretion system
5.5) Type VII secretion system
Defensive virulence factors
1) Antiphagocytosis
2) Anti-proteolysis
3) Cellular metabolism
4) Phase variation
5) Serum resistance
7) Ig protease
8) Stress protein
9) Complement Protease
Nonspecific virulence factor
1) Iron uptake system
2) Magnesium uptake system
3) Exoenzyme
Regulation of virulence-associated genes
1) Regulation