About Pseudomonas

General information:
Ubiquitous bacteria that belong to the γ-Proteobacteria.
Contains the clinically important human pathogen P. aeruginosa, the agriculturally important plant pathogen P. syringae, and the nonpathogenic bioremediation agent P. putida.
P. aeruginosa is a major opportunistic human pathogen, notable for its ability to form biofilm and best-characterized quorum-sensing systems among Gram-negative bacteria.
P. aeruginosa can cause a variety of opportunistic infections ranging from eye infections in contact lens wearers to burn and wound infections leading to septic shock.
Lung infections in cystic fibrosis patients.
Selected genomes:comparative pathogenomics
P. aeruginosa LESB58, 6601757 bp, NC_011770
P. aeruginosa PA7, 6588339 bp, NC_009656
P. aeruginosa PAO1, 6264404 bp, NC_002516
P. aeruginosa UCBPP-PA14, 6537648 bp, NC_008463
P. entomophila L48, 5888780 bp, NC_008027
P. fluorescens Pf-5, 7074893 bp, NC_004129
P. fluorescens Pf0-1, 6438405 bp, NC_007492
P. fluorescens SBW25, 6722539 bp, NC_012660
P. mendocina ymp, 5072807 bp, NC_009439
P. putida F1, 5959964 bp, NC_009512
P. putida GB-1, 6078430 bp, NC_010322
P. putida KT2440, 6181863 bp, NC_002947
P. putida W619, 5774330 bp, NC_010501
P. stutzeri A1501, 4567418 bp, NC_009434
P. syringae pv. phaseolicola 1448A, 5928787 bp, NC_005773
P. syringae pv. syringae B728a, 6093698 bp, NC_007005
P. syringae pv. tomato str. DC3000, 6397126 bp, NC_004578
P. syringae pv. phaseolicola 1448A large plasmid, 131950 bp, NC_007274
P. syringae pv. tomato str. DC3000 pDC3000A, 73661 bp, NC_004633
Related publications:
Stover CK, et al., 2000. Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature 406(6799):959-964.
Nelson KE, et al., 2002. Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440. Environ. Microbiol. 4(12):799-808.
Buell CR, et al., 2003. The complete genome sequence of the Arabidopsis and tomato pathogen Pseudomonas syringae pv. tomato DC3000. Proc. Natl. Acad. Sci. USA. 100(18):10181-10186.
Paulsen IT, et al., 2005. Complete genome sequence of the plant commensal Pseudomonas fluorescens Pf-5. Nat Biotechnol. 23(7):873-878.
Feil H, et al., 2005. Comparison of the complete genome sequences of Pseudomonas syringae pv. syringae B728a and pv. tomato DC3000. Proc. Natl. Acad. Sci. USA. 102(31):11064-11069.
Joardar V, et al., 2005. Whole-genome sequence analysis of Pseudomonas syringae pv. phaseolicola 1448A reveals divergence among pathovars in genes involved in virulence and transposition. J. Bacteriol. 187(18):6488-6498.
Vodovar N, et al., 2006. Complete genome sequence of the entomopathogenic and metabolically versatile soil bacterium Pseudomonas entomophila. Nat Biotechnol 24(6):673-679.
Lee DG, et al., 2006. Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial. Genome Biol 7(10):R90.
Yan Y, et al., 2008. Nitrogen fixation island and rhizosphere competence traits in the genome of root-associated Pseudomonas stutzeri A1501. Proc Natl Acad Sci USA 105(21):7564-7569.
Winstanley C, et al., 2009. Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the Liverpool Epidemic Strain of Pseudomonas aeruginosa. Genome Res 19(1):12-23.
Silby MW, et al., 2009. Genomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens. Genome Biol 10(5):R51.
Roy PH, et al., 2010. Complete genome sequence of the multiresistant taxonomic outlier Pseudomonas aeruginosa PA7. PLoS One 5(1):e8842.
Major virulence factors in Pseudomonas:
Fap (Functional amyloid in Pseudomonas)
Type IV pili
Effector delivery system
HSI-1 (Hcp secretion island I)
HSI-1 T6SS secreted effectors
HSI-2 T6SS secreted effectors
HSI-3 T6SS secreted effectors
LasB (Elastase)
TTSS (Type III secretion system)
TTSS secreted effectors
xcp secretion system
ExoA (Exotoxin A)
PLC (Phospholipase C)
Alkaline protease
Immune modulation
Alginate (Mucoid exopolysaccharide)
Quorum sensing
Nutritional/Metabolic factor

Genomic location of virulence-related genes in Pseudomonas:

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