About Anaplasma

General information:
Anaplasma belongs to the family Anaplasmataceae, in the order Rickettsiales and the class α-proteobacteria.
The Anaplasmataceae family includes six genera, Ehrlichia, Anaplasma, Aegyptianella, Wolbachia, Neorickettsia and Candidatus Neoehrlichia.
Vector-borne obligatory intracellular pathogen.
Bacteria from the Anaplasmataceae family develop within a cytoplasmic vacuole in the host cell cytoplasm, whereas other members of Rickettsiales order escape from the phagosome after entering the host cell and multiply in the cytoplasm before being released in the extracellular environment.
Anaplasmataceae that infects granulocytes, bone marrow progenitor cells, and endothelial cells of various mammalian species, including humans.
A. phagocytophilum is responsible for anaplasmosis and infects deer, dogs, cat, horses, ruminants, rodents, and humans, inducing human granulocytic anaplasmosis (HGA), an emerging infectious disease first detected in 1994.
E. chaffeensis infects deer, dogs, and humans, inducing canine ehrlichiosis and human monocytic ehrlichiosis.
A. marginale and E. ruminantium infect only domestic and wild ruminants.
Selected genomes:comparative pathogenomics
A. centrale str. Israel, 1206806 bp, NC_013532
A. marginale str. Florida, 1202435 bp, NC_012026
A. marginale str. St. Maries, 1197687 bp, NC_004842
A. phagocytophilum HZ, 1471282 bp, NC_007797
A. phagocytophilum str. Dog2, 1473302 bp, NC_021881
A. phagocytophilum str. HZ2, 1477581 bp, NC_021879
A. phagocytophilum str. JM, 1481598 bp, NC_021880
Related publications:
Brayton KA, et al., 2005. Complete genome sequencing of Anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins. Proc Natl Acad Sci U S A 102(3):844-9.
Dark MJ, et al., 2009. Conservation in the face of diversity: multistrain analysis of an intracellular bacterium. BMC Genomics 10:16.
Herndon DR, et al., 2010. Complete genome sequence of Anaplasma marginale subsp. centrale. J Bacteriol 192(1):379-80.
Lin M, et al., 2011. Global proteomic analysis of two tick-borne emerging zoonotic agents: anaplasma phagocytophilum and ehrlichia chaffeensis. Front Microbiol 2:24.
The intracellular niches of A. phagocytophilum and E. chaffeensis in human cells (From: Rikihisa Y, 2010. Anaplasma phagocytophilum and Ehrlichia chaffeensis: subversive manipulators of host cells. Nat Rev Microbiol 8(5):328-39.).

Major virulence factors in Anaplasma:
AipA (A. phagocytophilum invasion protein A)
Asp14 (14-kDa A. phagocytophilum surface protein)
Effector delivery system
Rvh T4SS
Rvh T4SS secreted effectors
Immune modulation
P44/Msp2 family (44 kDa major outer membrane protein/major surface protein 2)

Genomic location of virulence-related genes in Anaplasma:

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