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Klebsiella


General information:
The genus, Klebsiella, named after the microbiologist Edwin Klebs, are characterized as rod-shaped, Gram-negative γ-proteobacteria that can live in water, soil, and plants and are pathogenic to humans and animals
Characteristics:
For many years, the best characterized virulence determinants were capsule, lipopolysaccharide, siderophores, and type I and 3 fimbriae
Genomic sequence analysis has not revealed virulence factors that typify Gram-negative pathogens, such as specialized secretion systems (type III, IV and V) for the export of effectors or obvious toxins.
Disease:
K. pneumoniae causes a wide spectrum of both hospital- and community-acquired infections such as urinary tract infection, pneumonia, intraabdominal infection, bloodstream infection, meningitis and pyogenic liver abscess.
Genomes (comparative pathogenomics):
K. oxytoca E718, 6097032 bp, NC_018106
K. oxytoca KCTC 1686, 5974109 bp, NC_016612
K. pneumoniae 342, 5641239 bp, NC_011283
K. pneumoniae JM45, 5273813 bp, NC_022082
K. pneumoniae KCTC 2242, 5259571 bp, NC_017540
K. pneumoniae subsp. pneumoniae 1084, 5386705 bp, NC_018522
K. pneumoniae subsp. pneumoniae HS11286, 5333942 bp, NC_016845
K. pneumoniae subsp. pneumoniae MGH 78578, 5315120 bp, NC_009648
K. pneumoniae subsp. pneumoniae NTUH-K2044, 5248520 bp, NC_012731
K. pneumoniae subsp. rhinoscleromatis SB3432, 5270770 bp, NC_021232
K. variicola At-22, 5458505 bp, NC_013850
Plasmids:
K. pneumoniae KCTC 2242 pKCTC2242, 202852 bp, NC_017541
K. pneumoniae subsp. pneumoniae NTUH-K2044 pK2044, 224152 bp, NC_006625
Publications:
Liao TL, et al., 2012. Complete genome sequence of Klebsiella oxytoca E718, a New Delhi metallo-β-lactamase-1-producing nosocomial strain. J Bacteriol 194(19):5454.
Shin SH, et al., 2012. Complete genome sequence of Klebsiella oxytoca KCTC 1686, used in production of 2,3-butanediol. J Bacteriol 194(9):2371-2.
Shin SH, et al., 2012. Complete genome sequence of the 2,3-butanediol-producing Klebsiella pneumoniae strain KCTC 2242. J Bacteriol 194(10):2736-7.
Lin AC, et al., 2012. Complete genome sequence of Klebsiella pneumoniae 1084, a hypermucoviscosity-negative K1 clinical strain. J Bacteriol 194(22):6316.
Liu P, et al., 2012. Complete genome sequence of Klebsiella pneumoniae subsp. pneumoniae HS11286, a multidrug-resistant strain isolated from human sputum. J Bacteriol 194(7):1841-2.
Fevre C, et al., 2011. PCR-based identification of Klebsiella pneumoniae subsp. rhinoscleromatis, the agent of rhinoscleroma. PLoS Negl Trop Dis 5(5):e1052.
Figures:
Four well-characterized virulence factors in classical and hypervirulent K. pneumoniae (Kp) strains. (From: Paczosa MK, et al., 2016. Klebsiella pneumoniae: Going on the Offense with a Strong Defense. Microbiol Mol Biol Rev 80(3):629-61.)

Major virulence factors in Klebsiella:
Adherence
Type I fimbriae
Biofilm formation
Type 3 fimbriae
Efflux pump
AcrAB
Immune evasion
Capsule
Iron uptake
Aerobactin
Ent
Sal
Ybt
Nutritional factor
Allantion utilization
Regulation
RcsAB
RmpA
Secretion system
T6SS
Serum resistance
LPS
Toxin
Colibactin (K. pneumonia)
Location of virulence-associated genes in K. pneumoniae:
View the legend

View the legend


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