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Clostridium


General information:
Clostridium species are Gram-positive anaerobic spore-formers, representing ubiquitous bacilli commonly found throughout the world in soil, water, and gastrointestinal tracts of animals as well as humans.
From an evolutionary perspective, the anaerobic clostridia (or their archaic relatives) probably represent some of the first bacteria on Earth, with perhaps closely related aerobic bacilli evolving thereafter during the genesis of an oxygenated atmosphere.
Clostridium species have developed unique mechanisms for survival within and outside of numerous host types, as evidenced by the various diseases frequently linked to their protein toxins and spores.
The genus includes important pathogens (C. tetani, C. perfringens, C. botulinum and C. difficile), solvent producers (C. acetobutylicum and C. beijerinckii), cellulolytic strains (C. phytofermentans and C. thermocellum) and strains of importance in human physiology, bioremediation and wastewater treatment.
Characteristics:
Clostridial pathogens are well known for their ability to produce powerful toxins.
Disease:
C. botulinum: botulism
C. difficile: antibiotic-associated diarrhea, antibiotic-associated pseudomembranous colitis
C. perfingens: food poisoning, gas gangrene (clostridial myonecrosis), enteritis necroticans
C. tetani: tetanus
Genomes (comparative pathogenomics):
C. acetobutylicum ATCC 824, 3940880 bp, NC_003030
C. beijerinckii NCIMB 8052, 6000632 bp, NC_009617
C. botulinum A str. ATCC 19397, 3863450 bp, NC_009697
C. botulinum A str. ATCC 3502, 3886916 bp, NC_009495
C. botulinum A str. Hall, 3760560 bp, NC_009698
C. botulinum A2 str. Kyoto, 4155278 bp, NC_012563
C. botulinum A3 str. Loch Maree, 3992906 bp, NC_010520
C. botulinum B str. Eklund 17B, 3800327 bp, NC_010674
C. botulinum B1 str. Okra, 3958233 bp, NC_010516
C. botulinum E3 str. Alaska E43, 3659644 bp, NC_010723
C. botulinum F str. Langeland, 3995387 bp, NC_009699
C. difficile 630, 4290252 bp, NC_009089
C. novyi NT, 2547720 bp, NC_008593
C. perfringens ATCC 13124, 3256683 bp, NC_008261
C. perfringens SM101, 2897393 bp, NC_008262
C. perfringens str. 13, 3031430 bp, NC_003366
C. tetani E88, 2799251 bp, NC_004557
C. thermocellum ATCC 27405, 3843301 bp, NC_009012
Plasmids:
C. botulinum A3 str. Loch Maree pCLK, 266785 bp, NC_010418
C. botulinum B str. Eklund 17B pCLL, 47642 bp, NC_010680
C. botulinum B1 str. Okra pCLD, 148780 bp, NC_010379
C. botulinum Ba4 str. 657 pCLJ, 270022 bp, NC_012654
C. botulinum C str. 203U28 pC2C203U28, 106981 bp, NC_012219
C. perfringens str. 13 pCP13, 54310 bp, NC_003042
C. perfringens str. NCTC 8533B4D pCP8533etx, 64753 bp, NC_011412
C. tetani E88 pE88, 74082 bp, NC_004565
Publications:
Nolling J, et al., 2001. Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum. J. Bacteriol. 183(16):4823-4838.
Smith TJ, et al., 2007. Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 Strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids. PLoS ONE 2(12):e1271.
Sebaihia M, et al., 2007. Genome sequence of a proteolytic (Group I) Clostridium botulinum strain Hall A and comparative analysis of the clostridial genomes. Genome Res 17(7):1082-1092.
Sebaihia M, et al., 2006. The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome. Nat Genet 38(7):779-786.
Bettegowda C, et al., 2006. The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT. Nat. Biotechnol. 24(12):1573-1580.
Myers GS, et al., 2006. Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens. Genome Res. 16(8):1031-1040.
Shimizu T, et al., 2002. Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater. Proc. Natl. Acad. Sci. USA 99(2):996-1001.
Bruggemann H, et al., 2003. The genome sequence of Clostridium tetani, the causative agent of tetanus disease. Proc. Natl. Acad. Sci. USA 100(3):1316-1321.
Major virulence factors in Clostridium:
Exoenzyme
alpha-clostripain
kappa-toxin
mu-toxin
sialidase
Toxin
BoNT (C. botulinum)
C2 toxin (C. botulinum)
C3 toxin (C. botulinum)
CDT (C. difficile)
CPE
TcdA (C. difficile)
TcdB (C. difficile)
TeNT (C. tetani)
alpha-toxin (CpPLC)
alpha-toxin (novyi) (C. novyi)
alpha-toxin (septicum) (C. septicum)
beta-toxin
beta2-toxin
epsilon-toxin
iota-toxin
theta-toxin/PFO
Location of virulence-associated genes in C. perfringens:
View the legend


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