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| Pic |
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Homologous to the Pic protein identified in Shigella flexneri and enteroaggregative E. coli. ... |
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| Pic |
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Pic and ShET1 are encoded by the same chromosomal locus on opposite strands. Protease, mucinase. ... |
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Sat
(Secreted autotransporter toxin) |
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Belongs to SPATE (serine protease autotransporters to Enterobacteriaceae) proteins (eight known SPATE proteins: Sat of UPEC, Pet of EAEC, EspC of EPEC, Pic of EAEC and Shigella, SigA of Shigella, SepA of Shigella, Tsh of avian E. coli, and EspP of EHEC). Reside within PAI II of E. coli CFT073. ... |
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StcE
(Secreted protease of C1 esterase inhibitor from EHEC) |
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Encoded within the pO157 plasmid that belongs to the family of serine protease inhibitor. Secreted by a type II secretory apparatus also encoded within pO157 plasmid and is transcriptionally activated by the Ler, so the production of StcE is coupled with activation of the LEE genes. ... |
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| ToxB |
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A large 362-kDa protein encoded on the 93-kb plasmid that is present in O157:H7 and other EHEC strains. Shares sequence similarity with the large Clostridium toxin family, and to the Efa-1/LifA protein. ... |
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Tsh
(Temperature sensitive hemagglutinin) |
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The first known SPATE, Tsh, was identified as a temperature-sensitive protein that displayed hemagglutination of chicken red blood cells and cleavage of hemoglobin. Recently, Tsh has been shown to be associated with lethal avian pathogenic E. col (APEC) isolates and to contribute to the development of lesions and fibrin deposition in the air sacs of chickens. Often located on the ColV virulence plasmid in avian pathogenic E. coli strains. ... |
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CagA
(Cytotoxin-associated antigen) |
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Characterized by amino acid sequence polymorphism, primarily depending on the duplicaton of various numbers of a 34-amino-acid sequence located at the C-terminal region of the protein. Glu-Pro-Ile-Tyr-Ala(EPIYA) motifs present in the C-terminal half of CagA is the tyrosine phosphorylation site. ... |
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LigA
(L. pneumophila infectivity gene) |
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Protozoa specific gene. Required for replication in protozoa. ... |
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| CpnT |
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Secreted by ESX-5. CpnT is a two-domain protein in which the toxic activity resides in the C-terminus. ... |
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ESAT-6/CFP-10
(Early secretory antigenic target of 6 kDa/culture filtrate protein of 10 kDa) |
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Secreted protein. ESAT-6 and CFP-10 proteins are cotranscribed and form a tight 1:1 complex. A striking feature of the CFP-10/ESAT-6 complex is the long flexible arm formed by the C-terminus of CFP-10, which is essential for binding to the surface of cells. PDB code:1wa8. ... |
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