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| Exe T2SS |
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Essential for secretion of many virulence factors, such as aerolysin, proteases, haemolysin and DNase. ... |
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| T3SS |
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Similar to the Yersinia T3SS. A needle-like structure, often described as an "injectisome" that can inject effectors directly into the cytoplasm of target cells. Five effectors have been described: AexT, AexU, AopP, AopH and AopO. AexT and AexU are bifunctional toxins that contain a GTPase activating domain, allowing the interruption of host cell-signalling pathways and an ADP-ribosylating domain that can disrupt the host cytoskeleton, leading to the induction of apoptosis. AopP (NF-κB inhibitor), AopH (tyrosine phosphatase) and AopO (serine/threonine kinase), all are able to interrupt host cell signalling pathways and induce toxicity. ... |
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| T3SS secreted effectors |
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aopP. ... |
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| T3SS secreted effectors |
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T3SS. ... |
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| T3SS secreted effectors |
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aopP. ... |
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| T6SS |
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A phagetail-spike-like injectisome to translocate virulence determinants directly into the host cell cytoplasm. Four effectors of the T6SS have so far been characterized, Hcp1, Vgr1, Vgr2 and Vgr3. Hcp is a powerful effector substrate and once translocated into the targeted host cell cytoplasm, apoptosis ensues following caspase 3 activation. Hcp paralyzes macrophages to prevent phagocytosis. Vgr1 is an ADP-ribosylating toxin capable of interrupting the host cell cytoskeleton and inducing apoptosis. ... |
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| T6SS |
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A phagetail-spike-like injectisome to translocate virulence determinants directly into the host cell cytoplasm. Four effectors of the T6SS have so far been characterized, Hcp1, Vgr1, Vgr2 and Vgr3. Hcp is a powerful effector substrate and once translocated into the targeted host cell cytoplasm, apoptosis ensues following caspase 3 activation. Hcp paralyzes macrophages to prevent phagocytosis. Vgr1 is an ADP-ribosylating toxin capable of interrupting the host cell cytoskeleton and inducing apoptosis. ... |
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| T6SS secreted effectors |
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vgrG1 (Type VI secretion system effector VgrG1, ADP-ribosyltransferase ). ... |
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| Rvh T4SS |
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Similar to the virB/virD system of A. tumefaciens. The T4SS of Rickettsiales is characterized by an expansion of the virB4 and virB6 gene families and an absence of virB5. In addition, species in the family Anaplasmataceae have an expansion of virB2 and are missing virB1. The presence of multiple copies of T4SS components may facilitate environment- or host cell-dependent delivery of effector molecules. ... |
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| Rvh T4SS |
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Similar to the virB/virD system of A. tumefaciens. The T4SS of Rickettsiales is characterized by an expansion of the virB4 and virB6 gene families and an absence of virB5. In addition, species in the family Anaplasmataceae have an expansion of virB2 and are missing virB1. The presence of multiple copies of T4SS components may facilitate environment- or host cell-dependent delivery of effector molecules. ... |
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