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Efa-1/LifA
(EHEC factor for adherence/lymphocyte inhibitory factor) |
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Inhibits lymphocyte activation. Acting as adhesin in non-O157:H7 EHEC strains. ... |
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| EspC |
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A large (110kDa) secreted protein of EPEC that does not require the TTSS for export. A member of the SPATE (serine protease autotransporters of the Enterobacteriaceae) family. espC gene located within a pathogenicity island at 60 min on the chromosome of E. coli, may play a role as an accessory virulence factor in some EPEC strains. ... |
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| EspP |
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Encoded within the pO157 plasmid. Serine protease. Cleaves coagulation factor V. ... |
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| EtpA |
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Interacts with highly conserved regions of flagellin exposed at the tips of flagella, exploiting these long (<10~15 mm) appendages to tether EtpA adhesins that anchor bacteria on initial engagement of host cells. ... |
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FdeC
(Factor adherence E. coli) |
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Homology to Invasin and Intimin, belongs to inverse autotransporter family. Binding to epithelial cells and collagen I, II, V, VI. Aggregation. Kidney and bladder colonization. ... |
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| Heat-labile toxin (LT) |
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Secreted to the extracellular milieu by a type II secretion system. LT-I is plasmid-encoded. LT-II only produced by strains isolated from animals. ... |
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| Intimin |
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94-kDa outer-membrane protein encoded in the LEE. N-terminus of intimin anchors the protein in the EHEC outer membrane and exhibits little sequence variation. C-terminal end of intimin extends from the EHEC surface, binds to Tir, and exhibits extreme sequence variation that may be involved in tissue tropism. To date, sequence variations of the C-terminus have been proposed to define at least nine intmin subtypes represented by the Greek letters α through . The structure of the C-terminal end of intimin, alone (PDB code: 1F00)and in complex with Tir (PDB code: 1F02), has been determined. This region of intimin is composed of three tandem Ig-like domains followed by a C-type lectin-like domain that contains the Tir binding site. ... |
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| Intimin |
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94-kDa outer-membrane protein encoded in the LEE. N-terminus of intimin anchors the protein in the EPEC outer membrane and exhibits little sequence variation. C-terminal end of intimin extends from the EPEC surface, binds to Tir, and exhibits extreme sequence variation that may be involved in tissue tropism. To date, sequence variations of the C-terminus have been proposed to define at least nine intmin subtypes represented by the Greek letters α through . The structure of the C-terminal end of intimin, alone (PDB code: 1F00)and in complex with Tir (PDB code: 1F02), has been determined. This region of intimin is composed of three tandem Ig-like domains followed by a C-type lectin-like domain that contains the Tir binding site. ... |
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| Lymphostatin/LifA |
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Encoded outside the LEE. Very large protein of ~385 kDa. Contains sequence similarity to the glycosyltransferase region of the large clostridial cytotoxins. Also present in strains of EHEC, where it is known as Efa1. ... |
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Pet
(Plasmid-encoded enterotoxin) |
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Belongs to SPATEs subfamily. Encoded on the large virulence plasmid in close proximity to the gene encoding the AAF. ... |
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