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| FsaP |
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FsaP has some similarity to FimV from Pseudomonas aeruginosa, which is involved in assembly of Type IV secretin, and it also contains a conserved LysM domain, which in other proteins has been shown to bind peptidoglycan. ... |
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| Haemagglutinating pili |
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The first well studied adherence factors of H. influenzae, structural and functional homology to the Pap pili of UPEC and type 1 pili of Enterobacteriaceae, sometimes called fimbriae. hif cluster is absent from the completely sequenced genome of H. influenzae Rd. It is cloned and sequenced from several independent type b and non-typable strains. Expression of pili is a phase-variable phenomenon: the transcription of all pili genes is determined by reversible changes in the number of dinucleotide (TA) repeats located within the bidirectional promoter region between hifA and hifB. ... |
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Hap
(Haemophilus adhesion and penetration) |
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Autotransporter, analogous to H. influenzae IgA1 protease. Undergoes autoproteolysis, with extracellular release of the passenger domain. ... |
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| Hia/Hsf |
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Nearly all nontypable Haemophilus influenzae strains that are HMW1/HMW2 deficient, contain a gene homologous to hia, and conversely, strains that express HMW1/HMW2-like proteins uniformly lack the intact hia gene. The counterpart to hia is associated with expression of short, thin surface appendages referred to as fibrils and is called hsf. Hsf appears to be ubiquitous among typable H. influenzae, including both type b and non-type b strains. The N-terminal and C-terminal regions of two proteins are highly homologus, whereas the central segment of hsf is a trimeric duplication of hia. ... |
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HMW1/HMW2
(High-molecular-weight proteins) |
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Two HMWs are similar to each other and related to the filamentous hemagglutinin, a well-characterized adhesin from Bordetella pertussis. To date, the hmw genes have only been detected in nontypable strains. ... |
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| OapA |
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A surface-associated lipoprotein that is responsible for the transparent colony phenotype of H. influenzae. ... |
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| P5 protein |
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Major outer membrane protein, shares homology with E. coli OmpA. Antigenically variable from one train to another. ... |
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BabA
(Blood group antigen binding adhesin) |
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Two alleles: babA2 gene encodes the complete adhesin, whereas babA1 is defective due to the presence of a 10 bp repeat motif which results in the elimination of the start codon and the lack of Leb antigen-binding activity. babA2-genopositive H. pylori usually coexists with other disease-related H. pylori virulence-factor genes, such as vacA s1 and cagA. ... |
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HopZ
(H. pylori outer membrane protein) |
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Regulated by slipped-strand repair mechanism (CT dinucleotide repeats in signal-peptide coding region). ... |
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SabA
(Sialic acid-binding adhesin) |
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Mediates binding to the structurally related siayl-Lewis x/a antigen, allow more intimate but weaker adherence. ... |
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