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CBPs
(Choline binding proteins) |
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Surface protein: choline-binding. The TA phosphorylcholine esterase Pce (also known as CbpE and LytD) involved in the distribution and restructuration of the content of choline in the cell wall, and in modulating indirectly the activity of other CBPs and the pathogen-host interactions. The in vivo activity of Pce is associated to nasopharynx colonization and adherence to human epithelial cells. CbpG is a multifunctional protein with proteolytic and adhesin function. ... |
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FBPs
(Fibronectin binding proteins) |
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Surface protein: linked to the bacterial cell wall via C-terminal LPXTG motif. Including PrtF1 (protein F1) also known as SfbI (streptococcal fibronectin binding proteinI), SfbII/SOF (serum opacity factor), FbaA, FbaB, FBP54 (fibronectin-binding protein 54), protein F2, PFBP (pyogene fibronectin-binding protein). ... |
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| FbsA |
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Streptococcal surface protein, contains long tandem repeating elements, the number of repeats vary significantly between different strains, C-terminal domains LPXTGX, associated with attachment to the cell wall. ... |
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FbsB
(Fg-binding surface protein B) |
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FbsA has the LPXTG motif, a specific signal for cell wall anchoring. FbsB is devoid of such a motif. The surface localization of FbsB in the absence of LPXTG motif suggests that it might belong to the group of anchorless adhesins. ... |
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Lmb
(Laminin-binding protein) |
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Lmb is an extracellular protein that was first identified in S. agalactiae. Homologs of this protein were reported in S. pyogenes and S. pneumonia and termed Lbp and AdcAII, respectively. ... |
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PavA
(Pneumococcal adherence and virulence factor A) |
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PavA was the first Fibronectin-binding protein identified in S. pneumoniae and shares about 70% sequence identity with the Fibronectin-binding proteins FBP54 of S. pyogenes and FbpA of S. gordonii. ... |
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PavB
(Pneumococcal adhesion and virulence factor B) |
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LPxTG-anchored protein. Repetitive sequences in PavB designated Streptococcal Surface REpeats (SSURE), interact with human fibronectin. ... |
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PfbA
(Plasmin and fibronectin-binding protein A) |
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C-terminal cell wall-anchoring region consisting of LPKTG as the sortase-recognising motif. A surface adhesin and invasin that binds to human fibronectin and plasminogen of the host extracellular matrix. ... |
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PI-1
(Pilus island 1) |
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The genes encoding pili are located within 2 distinct loci, denoted pilus islands 1 and 2 (PI-1 and PI-2), the latter having 2 allelic variants (PI-2a and PI-2b). Each pilus island (PI) comprises 3 genes that encode structural proteins with a characteristic LPXTG anchoring motif recognised by sortase transpeptidases: backbone (Bkb) subunit (forming the polymeric shaft of the pilus), ancillary subunit 1 (An1, the functional tip), and ancillary subunit 2 (An2, the C-terminal anchor following attachment to peptidoglycan in the cell wall by sortase A). ... |
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PI-2a
(Pilus island 2a) |
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Mediating cell attachment, promoting the invasion of human endothelial cells and may facilitate paracellular translocation across the epithelial barrier. Promoting biofilm formation. ... |
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