|
Tbp
(Transferrin-binding protein) |
 |
Instead of using siderophores, H. influenzae and other species, such as N. gonorrohoeae and N. meningitidis, express proteins at the their cell surface that specifically bind hot iron-carrying molecules (such as transferrin and lactoferrin) and scavenge iron from these host molecules. Two H. influenzae iron-repressible transferrin-binding protein called Tbp1 and Tbp2 were identified. ... |
|
| FeoAB |
|
A feoB mutant of L. pneumophila has a lowered Fe2+ uptake and is attenuated for intracellular growth. ... |
|
FrgA
(fur regulated gene) |
|
Homology with the aerobactin synthesases IucA and IucC. Putative hydroxamate siderophore, iron is critical for L. pneumophila extracellular replication, intracellular infection, and virulence. ... |
|
| IraAB |
|
IraA, a methyltransferase, is critical for virulence. IraB, a homologue of di- and tri-peptide transporters, may involve in a novel method of iron acquisition which may utilize iron-loaded peptides. ... |
|
SvpA
(Surface-virulence associated protein) |
|
The transcription of svpA gene is not controlled by PrfA. HupDCG system of haem transport with cooperating proteins Hbp1 (SvpA) and Hbp2. ... |
|
| FbpABC |
|
Encodes a periplasmic-binding protein-dependent iron transport system necessary for the utilization of iron bound to transferrin or iron chelates, FbpA is the periplasmic Fe3+ binding protein. ... |
|
| HmbR |
|
The gene encoding the hemoglobin receptor, hmbR, is located downstream of a gene involved in the catabolism of heme, hemO. Expression of HmbR undergoes phase variation due to slip-strand mispairing of poly(G) tracts within the hmbR gene. The advantage associated with phase-varying surface proteins is evasion of the host immune response. ... |
|
| HpuAB |
|
Expression of HpuAB undergoes phase variation due to slip-strand mispairing of poly(G) tracts within the hpuA gene. ... |
|
Lbp
(Lactoferrin-binding protein) |
|
The entry site of N. meningitidis into the body is the nasopharynx, where lactoferrin predominates as the main source of iron. ... |
|
Tbp
(Transferrin-binding protein) |
|
The tbp locus is a bicistronic operon consisting of tbpA and tbpB. Unlike the case for many other genes of Neisseria, there is no phase variation of the transferrin receptor. ... |
|
| | | |
