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| Acinetobactin |
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An iron-chelating molecule composed of equimolar quantities of 2,3-dihydroxybenzoic acid (DHBA), L-threonine, and N-hydroxyhistamine. ... |
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Hal
(Heme-acquisition leucine-rich repeat protein) |
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Includes an N-terminal near-iron transporter (NEAT) domain, several internal leucine-rich repeat (LRR) regions, and a C-terminal sortase-like cell wall anchor. ... |
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IlsA
(Iron-regulated leucine rich surface protein type A) |
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The three conserved domains: NEAT (NEAr iron Transporter), LRR (Leucine-Rich Repeat) and SLH (Surface Layer Homology). Specifically expressed in the insect hemocoel and under iron-depleted conditions. ... |
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| Petrobactin |
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Catechol-based siderophore. The biosynthetic pathway for petrobactin (the asb operon), the petrobactin-iron complex receptor (FhuA), import permeases (FpuB/FatC/FatD), ATPases (FpuC/FatE), and the petrobactin exporter (ApeX). ... |
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FupA
(Fe utilization protein A) |
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FupA and FslE are paralogs belonging to a family of proteins unique to Francisella. Both FupA and FslE fold as β- barrels in the outer membrane with amino-terminal periplasmic domains. ... |
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| Rhizoferrin |
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Siderophore-mediated Iron acquisition. Siderophore biosynthesis involves enzymes FslA and FslC, while export across the inner membrane is mediated by FslB. Uptake of the rhizoferrin- ferric iron complex is effected by the siderophore receptor FslE in the outer membrane in a TonB-independent process, and FslD is responsible for uptake across the inner membrane. ... |
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Hgp
(Hemoglobin-binding protein) |
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H. influenzae has an absolute requirement for exogenously supplied heme for aerobic growth. Most of the pathway converting δ-aminolevulinic acid to heme is lost. So H. influenzae has derived several mechanism to use host heme-hemopexin, hemoglobin-haptoglobin as sources of heme iron for growth. Three hemoglobin- and hemoglobin-haptoglobin binding protein genes, hgpA, hgpB, and hgpC, contain lengths of tetrameric CCAA repeats. ... |
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HhuA
(Hemoglobin:haptoglobin complexes binding protein) |
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Similar to HgpA, mediates binding of both hemoglobin:haptoglobin complexes and free hemoglobin. ... |
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| HitABC |
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hitA encodes a periplasmic ferric-binding protein A (FbpA), a high-affinity iron-binding protein belonging to the transferrin superfamily. hitB encodes a cytoplasmic permease. hitC encodes ATP-binding protein. ... |
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| HxuABC |
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HxuA is a 100-kDa protein that binds heme-hemopexin, HxuB is a 60 kDa protein involved in the release of HxuA from the cell surface into the medium, HxuC is involved in the transport of heme within the cell. ... |
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