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CNF-1
(Cytotoxic necrotizing factor 1) |
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Expressed by certain uropathogenic and neonatal meningitis-causing strains of E. coli. Belongs to a unique group of large cytotoxins that cause constitutive activation of Rho GTPase. Two types (CNF-1 and CNF-2) have 90% conserved residues over 1014-amino-acid sequences and hare the same catalytic activity. CNF1 is encoded by the chromosome, whereas a transmissible plasmid called pVir codes for CNF2. ... |
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| Heat-labile toxin (LT) |
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Secreted to the extracellular milieu by a type II secretion system. LT-I is plasmid-encoded. LT-II only produced by strains isolated from animals. ... |
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Stx
(Shiga toxin) |
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Also known as verotoxin, verocytotoxin or Shiga-like toxins, are produced by several enteric pathogens, most importantly Shigella dysenteriae (serotype 1 only) and EHEC. The Stx family contains two subgroups: Stx1 and Stx2, that share approximately 55% amino acid homology. Retrograde transport to the ER via a Rab6-dependent pathway. ... |
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Stx
(Shiga toxin) |
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Also known as verotoxin, verocytotoxin or Shiga-like toxins, are produced by several enteric pathogens, most importantly Shigella dysenteriae (serotype 1 only) and EHEC. The Stx family contains two subgroups: Stx1 and Stx2, that share approximately 55% amino acid homology. Retrograde transport to the ER via a Rab6-dependent pathway. ... |
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CARDS toxin
(Community Acquired Respiratory Distress Syndrome toxin) |
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Homologous to the S1 subunit of pertussis toxin. PDB code:4TLW. A triangular molecule with N-terminal mART and C-terminal tandem β-trefoil domains associate to form an overall architecture distinct from other well-recognized ADP-ribosylating bacterial toxins. ... |
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ExoA
(Exotoxin A) |
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Secreted by type II secretion pathway. Transported to the endoplasmic reticulum (ER) via a coat protein COPI-dependent retrograde pathway dependent on a KDEL motif. ... |
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| SpvB |
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PDB accession: 2GWL. SpvB-mediated actin depolymerization is associated with an accumulation of cells in the G2/M phase, eventually resulting in apoptotic cell death. ... |
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| Typhoid toxin |
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Classic cytolethal distending toxins (CDTs) are three component AB toxins, composed of CdtA, CdtB and CdtC. CdtA and CdtC mediate target cell binding and membrane translocation of CdtB, which then induces DNA damage, most probably through its nuclease activity. In the case of S. typhi, however, genes encoding CdtA and CdtC are absent. CdtB from S. typhi is produced with the pertussis-like toxins PltA and PltB only inside the host cell and is then secreted from the infected Cell in a PltA/B-Dependent manner and acts then as a classical CDT from outside. Typhoid toxin seemed to have evolved from the combination of the activities of two exotoxin ancestors, CDT and pertussis toxins. ... |
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| Shiga toxin |
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Also known as verotoxin, verocytotoxin or Shiga-like toxins, are produced by several enteric pathogens, most importantly Shigella dysenteriae (serotype 1 only) and EHEC. ... |
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ChxA
(Cholix toxin) |
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PDB code: 3Q9O. Inhibiting protein synthesis, resulting in cell death. Inducing apoptosis. ... |
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