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| Type IV secretion system |
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C. jejuni pVir is a 37-kb plasmid harboring 54 predicted ORFs, contains genes for homologs of Com and Vir proteins, and shows great similarities to type IV secretion proteins found in cag PAI of H. pylori. ... |
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| Dot/Icm T4SS |
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Highly homologous to the L. pneumophila Dot/Icm system. Facilitates the translocation of many bacterial effector proteins across the bacterial and vacuole membranes to enter the host cytoplasm where the effector proteins mediate their specific activities to manipulate a variety of host cell processes. ... |
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| Type IV secretion system |
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A pilus-like structure crossing the inner and outer membrane of the bacterium and like a needle inserts into the membrane of host cell. ... |
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Dot/Icm
(Defect in organella trafficking/intracellular multiplication) |
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14 genes share detectable homology to the tra/trb genes of col1b-P9 plasmid, a member of the IncI class of conjugal plasmids. The second type IV secretion apparatus lvh (Legionella vir homologs) system is poorly characterized. Its 11 genes are located on a genomic-island-like region. It might play a role in the efficiency of host cell infection by L. pneumophila grown at lower temperatures. However, the specific substrates of this system have not yet been identified. ... |
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Rvh T4SS
(Rickettsiales vir homolog (rvh) T4SS) |
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All sequenced Rickettsia genomes encode a P-T4SS similar to the vir archetype of Agrobacterium tumefaciens and related systems, and this T4SS is encoded across all genomes in the rickettsial families Rickettsiaceae, Anaplasmataceae, and Midichloriaceae. Lacks a homolog of VirB5, the minor pilin subunit that is indispensable for pilus formation but not substrate transfer. A defining feature of the rvh T4SS is the proliferation of genes encoding RvhB6 proteins, which are predicted IM channel components of the VirB6/TrbL family that are required for substrate transfer in P-T4SSs. Three other components are encoded by duplicate genes within the rvh T4SS: RvhB4a and RvhB4b--homologous to VirB4 (IM ATPase), RvhB9a and RvhB9b--homologous to Vir9 (participating with VirB7 and VirB10 in the OM pore of the T4SS), two VirB8-like channel proteins, RvhB8a and RvhB8b. ... |
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BtpA/Btp1/TcpB
(TIR domain-containing protein) |
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Translocated by Brucella into host cells. May be substrates of the VirB T4SS. Contains Toll-interleukin-1 receptor (TIR) domain. ... |
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| BtpB |
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Translocated into host cells. May be the substrates for the VirB T4SS. TIR domain-containing protein BtpB also interfere with Toll like receptor signalling to temper the host inflammatory response. Also modulates microtubule dynamics. ... |
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CagA
(Cytotoxin-associated antigen) |
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Characterized by amino acid sequence polymorphism, primarily depending on the duplicaton of various numbers of a 34-amino-acid sequence located at the C-terminal region of the protein. Glu-Pro-Ile-Tyr-Ala(EPIYA) motifs present in the C-terminal half of CagA is the tyrosine phosphorylation site. ... |
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LigA
(L. pneumophila infectivity gene) |
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Protozoa specific gene. Required for replication in protozoa. ... |
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| Rvh T4SS |
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Similar to the virB/virD system of A. tumefaciens. The T4SS of Rickettsiales is characterized by an expansion of the virB4 and virB6 gene families and an absence of virB5. In addition, species in the family Anaplasmataceae have an expansion of virB2 and are missing virB1. The presence of multiple copies of T4SS components may facilitate environment- or host cell-dependent delivery of effector molecules. ... |
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