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| TTSS secreted effectors |
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Mxi-Spa TTSS effectors controlled by VirB. ... |
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| T3SS1 secreted effectors |
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T3SS1 secreted effectors. ... |
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| T3SS2 secreted effectors |
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T3SS2 secreted effectors. ... |
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| TTSS secreted effectors |
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TTSS effectors. ... |
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| Ysa TTSS effectors |
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| T3SS |
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Similar to the Yersinia T3SS. A needle-like structure, often described as an "injectisome" that can inject effectors directly into the cytoplasm of target cells. Five effectors have been described: AexT, AexU, AopP, AopH and AopO. AexT and AexU are bifunctional toxins that contain a GTPase activating domain, allowing the interruption of host cell-signalling pathways and an ADP-ribosylating domain that can disrupt the host cytoskeleton, leading to the induction of apoptosis. AopP (NF-κB inhibitor), AopH (tyrosine phosphatase) and AopO (serine/threonine kinase), all are able to interrupt host cell signalling pathways and induce toxicity. ... |
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TTSS
(Type III secretion system) |
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B. pertussis has genes that could encode a TTSS, but they seem not to be expressed. B. bronchiseptica and ovine B. parapertussis strains, by contrast, do have a functional TTSS. ... |
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| Bsa T3SS |
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Mxi-SpaA like T3SS, shares homology to Salmonella SPI-1 and Shigella T3SSs. Two additional T3SSs are discovered in B. Pseudomallei. T3SS1 is only present in B. pseudomallei and not in Burkholderia mallei or Burkholderia thailandensis, whereas T3SS2 and T3SS3 (Bsa) are present in all three species. T3SS1 and T3SS2 are closely related to the T3SS of the plant pathogens R. solanacearum and Xanthomonas spp. T3SS1 and T3SS2 are required during B. pseudomallei infection of tomato plants but not for infection of hamsters. ... |
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TTSS
(Type III secretion system) |
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Type III secretion genes of Proteobacteria are usually tightly clustered in a pathogenicity island or on a plasmid, suggesting that they can be horizontally transferred as a unit. But chlamydial type III secretion loci are dispersed in at least three different chromosomal locations. The G+C contents of these loci, are similar to the overall G+C content of the genome, suggesting that the type III system has been present in chlamydiae for a long time and has been essential to their parasitic lifestyle. On the basis of this loose retainment of operon organization and the significant divergence from other type III systems, it has been postulated an ancient acquisition of the type III system by chlamydiae. ... |
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TTSS
(Type III secretion system) |
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Encoded on the pathogenicity island known as the locus of enterocyte effacement (LEE). Injects Tir and other effector molecules directly into the host cell. Effector molecules activate cell-signaling pathways, causing alterations in the host cell cytoskeleton and resulting in the depolymerization of actin and the loss of microvilli. ... |
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