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| P66 |
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A uniquely large porin: it is predicted to have 22 or 24 transmembrane strands, oligomerizes as a heptamer or octamer, and has an estimated diameter of ~19A with a central constriction of ~8A. ... |
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| P66 |
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A uniquely large porin: it is predicted to have 22 or 24 transmembrane strands, oligomerizes as a heptamer or octamer, and has an estimated diameter of ~19A with a central constriction of ~8A. ... |
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| P66 |
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A uniquely large porin: it is predicted to have 22 or 24 transmembrane strands, oligomerizes as a heptamer or octamer, and has an estimated diameter of ~19A with a central constriction of ~8A. ... |
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| RevA |
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Encoded on the circular plasmid 32 (cp32) family of plasmids. A surface-exposed 17-kDa outer membrane protein binds host extracellular matrix (ECM) component fibronectin. ... |
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| RevA |
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Encoded on the circular plasmid 32 (cp32) family of plasmids. A surface-exposed 17-kDa outer membrane protein binds host extracellular matrix (ECM) component fibronectin. ... |
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| RevA |
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Encoded on the circular plasmid 32 (cp32) family of plasmids. A surface-exposed 17-kDa outer membrane protein binds host extracellular matrix (ECM) component fibronectin. ... |
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| VlsE |
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The vls (VMP-like sequence) locus in B31 is carried on linear plasmid 28-1 (lp28-1). Features of the vls locus include a telomeric location of the vlsE gene, an inverse orientation of vlsE and the silent cassettes, the presence of nearly perfect inverted repeats of 100 bp near the 5' end of vlsE and high G+C content and GC skew. vlsE is the expression locus , which encodes the outer surface-localized VlsE lipoprotein. In strain B31, the vlsE gene is localized near a hairpin telomere with the 15 silent cassettes located adjacent to and upstream of vlsE, but in the opposite orientation. A similar arrangement of vls components has been found in a variety of other Borrelia strains and species. Small stretches of information are transferred from a series of silent cassettes in the vls locus to generate an expressed mosaic vlsE gene version that contains genetic information from several different silent cassettes, resulting in 1040 possible vlsE sequences. Changes in the sequence of vlsE occur continuously during mammalian infection and consist of random, segmental, unidirectional recombination events between the silent cassettes and the cassette region of vlsE. The mechanism of recombination is largely unknown, but requires the RuvAB Holliday junction branch migrase. ... |
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| VlsE |
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The vls (VMP-like sequence) locus in B31 is carried on linear plasmid 28-1 (lp28-1). Features of the vls locus include a telomeric location of the vlsE gene, an inverse orientation of vlsE and the silent cassettes, the presence of nearly perfect inverted repeats of 100 bp near the 5' end of vlsE and high G+C content and GC skew. vlsE is the expression locus , which encodes the outer surface-localized VlsE lipoprotein. In strain B31, the vlsE gene is localized near a hairpin telomere with the 15 silent cassettes located adjacent to and upstream of vlsE, but in the opposite orientation. A similar arrangement of vls components has been found in a variety of other Borrelia strains and species. Small stretches of information are transferred from a series of silent cassettes in the vls locus to generate an expressed mosaic vlsE gene version that contains genetic information from several different silent cassettes, resulting in 1040 possible vlsE sequences. Changes in the sequence of vlsE occur continuously during mammalian infection and consist of random, segmental, unidirectional recombination events between the silent cassettes and the cassette region of vlsE. The mechanism of recombination is largely unknown, but requires the RuvAB Holliday junction branch migrase. ... |
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| VlsE |
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The vls (VMP-like sequence) locus in B31 is carried on linear plasmid 28-1 (lp28-1). Features of the vls locus include a telomeric location of the vlsE gene, an inverse orientation of vlsE and the silent cassettes, the presence of nearly perfect inverted repeats of 100 bp near the 5' end of vlsE and high G+C content and GC skew. vlsE is the expression locus , which encodes the outer surface-localized VlsE lipoprotein. In strain B31, the vlsE gene is localized near a hairpin telomere with the 15 silent cassettes located adjacent to and upstream of vlsE, but in the opposite orientation. A similar arrangement of vls components has been found in a variety of other Borrelia strains and species. Small stretches of information are transferred from a series of silent cassettes in the vls locus to generate an expressed mosaic vlsE gene version that contains genetic information from several different silent cassettes, resulting in 1040 possible vlsE sequences. Changes in the sequence of vlsE occur continuously during mammalian infection and consist of random, segmental, unidirectional recombination events between the silent cassettes and the cassette region of vlsE. The mechanism of recombination is largely unknown, but requires the RuvAB Holliday junction branch migrase. ... |
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| VlsE |
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The vls (VMP-like sequence) locus in B31 is carried on linear plasmid 28-1 (lp28-1). Features of the vls locus include a telomeric location of the vlsE gene, an inverse orientation of vlsE and the silent cassettes, the presence of nearly perfect inverted repeats of 100 bp near the 5' end of vlsE and high G+C content and GC skew. vlsE is the expression locus , which encodes the outer surface-localized VlsE lipoprotein. In strain B31, the vlsE gene is localized near a hairpin telomere with the 15 silent cassettes located adjacent to and upstream of vlsE, but in the opposite orientation. A similar arrangement of vls components has been found in a variety of other Borrelia strains and species. Small stretches of information are transferred from a series of silent cassettes in the vls locus to generate an expressed mosaic vlsE gene version that contains genetic information from several different silent cassettes, resulting in 1040 possible vlsE sequences. Changes in the sequence of vlsE occur continuously during mammalian infection and consist of random, segmental, unidirectional recombination events between the silent cassettes and the cassette region of vlsE. The mechanism of recombination is largely unknown, but requires the RuvAB Holliday junction branch migrase. ... |
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