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Ata
(Acinetobacter trimeric autotransporter) |
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Important for adhesion to host extracellular matrices (collagen and laminin) and basal membrane components. ... |
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BslA
(B. anthracis S-layer protein A) |
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Consists of a canonical Ig-like domain, to which is appended a three-stranded "cap" that is highly hydrophobic in character, rich in leucine residues as well as isoleucine, valine, and alanine. This cap comprises a surface-exposed hydrophobic patch. ... |
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BadA/Vomp
(Bartonella adhesin A/variably expressed outer membrane proteins) |
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BadA of B. henselae and Vomps of B. quintana belong to the class of trimeric autotransporter adhesins, which also includes YadA of Yersinia enterocolitica, Hia and Hsf of Haemophilus influenzae, and UspA of Moraxella catarrhalis. ... |
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BapC
(B.pertussis autotransporter protein C) |
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BapC, like BrkA, appear to be mainly surface associated rather than secreted. Involved in adherence to host cells. ... |
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FHA
(Filamentous haemagglutinin) |
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Synthesized as a 367-kDa precursor FhaB, modified at its N-terminus and cleaved at its C terminus to form the mature 220-kDa FHA protein. FHA is a large and highly immunogenic hairpin-shaped molecule possessed separate FHA-binding domains. FhaC is a pore-forming outer membrane protein that interacts with FhaB allowing for secretion of the adhesin. In the absence of FhaC, FHA is no longer secreted and gets degraded. FHA and FhaC have been classified as members of the two-partner secretion system (TPS). ... |
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| Pertactin |
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Contains an Arg-Gly-Asp (RGD) tripeptide motif as well as several proline-rich regions and leucine-rich repeats. 16-stranded parallel β-helix with a V-shaped cross-section. PDB code: 1DAB. ... |
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TcfA
(Tracheal colonization factor) |
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Exclusively produced by B.pertussis. Contains three RGD motifs and has a high proline content. ... |
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| BigA |
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Harbors a bacterial Ig-like (BIg-like) domain present in adhesins from the invasin/intimin family. Adhesin targets the bacteria to the cell-cell junction membrane in polarised cells promoting the adhesion and invasion of epithelial cells through cytoskeleton modifications. ... |
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BigB
(Bacterial Immunoglobulin Gene B) |
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Contains a BIg-like domain, similar to the one present in BigA. Involved in adhesion to epithelial cells and targets proteins involved in cell-cell and cell-matrix interactions. ... |
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| BmaA |
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Monomeric autotransporter that shares significant sequence similarities with BmaC. The bmaA and bmaC loci from Brucella melitensis are pseudogenes. ... |
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