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VF category: Metabolic adaptation (total 763 related VFs in database, current show from 11 to 20)
 
VF Bacteria Brief description
Hpt
(Hexose phosphate transporter)
Listeria
(L. monocytogenes EGD-e)
 Belongs to the organophosphate:inorganic phosphate antiporter (OPA) family, of the major facilitator superfamily of permease. Hpt is the first virulence factor to be identified as specifically involved in the replication phase of a facultative intracellular pathogen. It could be termed "metabolic" virulence factor and represent an example of the concept in the biology of host-pathogen interaction: adaptation to parasitic life often involves the mimicry of eukaryotic host functions by microbial virulence factors. Expression of the Hpt permease is tightly cotrolled by the PrfA. ...
LipF
Mycobacterium
(M. tuberculosis H37Rv)
 Annotated as a lipase/esterase, dramatically upregulated at low pH, a possible function of lipF could be to hydrolyze toxic fatty acids present in caseous necrotic debris during tuberculosis or it may modify the external cell wall as an adaptive response to acid damage. ...
Nitrate reductase
Mycobacterium
(M. tuberculosis H37Rv)
 NarX function as a respiratory fused nitrate reductase (three different domains present in this protein encode the difference subunits of nitrate reductase: the N-terminal domain showing similarity to narG, the central domain showing homology with narJ and the C-terminus showing homology to narI). NarGHJI is a membrane-bound nitrate reductase complex. NarK2, a putative nitrite-extrusion protein. ...
PanC/PanD
Mycobacterium
(M. tuberculosis H37Rv)
 Lipid biosynthesis and metabolism play a pivotal role in the intracellular replication and persistence of M. tuberculosis. Pantothenic acid (vitamin B5) is an essential molecule required for the synthesis of coenzyme A and acyl carrier protein (ACP). PanC (pantothenate synthetase) and PanD (aspartate-1-decarboxylase) involved in pantothenate biosynthesis. ...
AnsP
Francisella
(F. novicida U112)
 Belongs to the Phagosomal transporter (Pht) subclass of major facilitator superfamily that is exclusively found among intracellular pathogenic bacteria. ...
AnsP
Francisella
(F. philomiragia subsp. philomiragia ATCC 25017)
 Belongs to the Phagosomal transporter (Pht) subclass of major facilitator superfamily that is exclusively found among intracellular pathogenic bacteria. ...
AnsP
Francisella
(F. tularensis subsp. holarctica FTNF002-00)
 Belongs to the Phagosomal transporter (Pht) subclass of major facilitator superfamily that is exclusively found among intracellular pathogenic bacteria. ...
AnsP
Francisella
(F. tularensis subsp. holarctica LVS)
 Belongs to the Phagosomal transporter (Pht) subclass of major facilitator superfamily that is exclusively found among intracellular pathogenic bacteria. ...
AnsP
Francisella
(F. tularensis subsp. holarctica OSU18)
 Belongs to the Phagosomal transporter (Pht) subclass of major facilitator superfamily that is exclusively found among intracellular pathogenic bacteria. ...
AnsP
Francisella
(F. tularensis subsp. mediasiatica FSC147)
 Belongs to the Phagosomal transporter (Pht) subclass of major facilitator superfamily that is exclusively found among intracellular pathogenic bacteria. ...
   


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