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LPS |
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LpxM dependent acylation of lipid A is essential for A. baumannii desiccation survival, a key resistance mechanism for survival in hospital environments. ... |
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LPS |
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The endotoxic activity of purified LPS from B. henselae was shown to be 1,000-10,000-fold lower than that of enterobacterial LPS. Some of the structural features of B. henselae LPS are shared by the low-endotoxic LPS of other intracellular bacteria that cause chronic infections - penta-acylation of lipid A of Chlamydia trachomatis and the presence of a long-chain fatty acid in the lipid A of Legionella pneumophila. ... |
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LPS |
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B. pertussis LPS lacks a repetitive O-antigen due to the deletion of the wbm cluster. Two types, band A and B. The band A trisaccharide from B. pertussis 1414 is composed of N-acetyl-D-glucosamine (D-GlcNAc), 2,3-diacetamido-2,3-dideoxy-D-mannuronic acid (D-ManNAc3NAcA), and 2-acetamido-4-methylaminofucose (FucNAc4NMe). The B. pertussis bpl locus is required for the biosynthesis of trisaccharide to generate band A LPS. ... |
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LPS (Lipopolysaccharide) |
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Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds). In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS. This is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. ... |
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LOS (Lipooligosaccharide) |
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LOS diversity is important for the ability to colonize a wide variety of hosts and intestinal niches. The ability to generate variation at high frequency, the molecular mimicry evident in LOS structure support a role in the avoidance of host defences. The similarity of LOS structures to host gangliosides and the subsequent ability to generate crossreacting antibodies forms the pathological basis for the association of preceding C. jejuni infection with Guillain-Barre syndrome. ... |
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LPS |
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The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion. ... |
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LOS |
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lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence. lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-α(1-4)β-Gal LPS structure. But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. ... |
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LPS |
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Under-phosphorylation and under-acylation of lipid A compared with enterobacterial lipid A. The average length of the fatty acid chains in H. pylori lipid A is longer (16 to 18 carbons) than in E. coli (12 to 14 carbons). ... |
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LPS |
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In K. pneumoniae there are nine main O-serotypes. Three of these, O1, O2, and O3, are responsible for almost 80% of all Klebsiella infections. Compared with other Enterobacteriaceae, such as Escherichia coli 161 defined O serotypes and Shigella flexneri at least 47 O serotypes, Klebsiella has a surprisingly low number of reported O serotypes which promises a more viable alternative for vaccine development compared with K-antigen-based vaccines. The O-antigen biosynthesis enzymes are encoded on the rfb locus. ... |
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LPS |
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O-side chain is made up of homopolymer repeats of a single sugar residue designated legionaminic acid, and the core region is highly O-acetylated providing hydrophobic characteristic on the LPS structure. ... |
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