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| Glycosyltransferase (total related VFs in database, current show from 1 to 5) |
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| alpha-toxin (novyi) |
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Belongs to the family of large clostridial cytotoxins which act on cells through the modification of small GTP-binding proteins. The family includes toxin A and B from C. difficile, the hemorrhagic and lethal toxin from C. sordellii, and the α-toxin from C. novyi. Unlike C. difficile toxins A and B and the variant toxin B recruit the nucleotide sugar UDP-glucose as cosubstrate, α-toxin uses UDP-GlcNAc as a cosubstrate. α-Toxin also utilizes UDP-glucose, but the Km is about 340 uM compared to 17 uM for UDP-glucNAc. ... |
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TcdA
(Toxin A) |
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The toxin genes tcdA and tcdB are situated on the C. difficile chromosome in a 19.6-kilobase (kb) pathogenicity locus (PaLoc), along with the three accessory genes tcdC, tcdR and tcdE. TcdA and TcdB are homologous to each other, to TcsH and TcsL of C. sordellii and to Tcnα of C. novyi. Because of their sequence homology, similar domain structure and glycosyltransferase properties these toxins are designated 'large clostridial cytotoxins'. ... |
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TcdB
(Toxin B) |
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Many forms of variant toxin B have been identified, which are functional chimeras of toxin B (reference strain VPI 10463) and C. sordellii lethal toxin, e.g., C. difficile toxin B from strain 1470 and strain 8864. Their substrate specificities resemble that of lethal toxin. C. difficile strain C34 produces a toxin B variant modifying Rho, Rac, and Cdc42 as well as R-Ras, Ral, and Rap. ... |
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TcdB
(Toxin B) |
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Many forms of variant toxin B have been identified, which are functional chimeras of toxin B (reference strain VPI 10463) and C. sordellii lethal toxin, e.g., C. difficile toxin B from strain 1470 and strain 8864. Their substrate specificities resemble that of lethal toxin. C. difficile strain C34 produces a toxin B variant modifying Rho, Rac, and Cdc42 as well as R-Ras, Ral, and Rap. ... |
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| CT166 |
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Glucosyltransferase. Large clostridial toxins. CT166. ... |
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