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| Metalloprotease (total related VFs in database, current show from 1 to 10) |
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| Anthrax toxin |
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atxA, a pXO1 gene required for transcription of the three toxin genes, also positively regulated encapsulation. The expression of atxA gene is not controlled by CO2. ... |
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BoNT
(Botulinum neurotoxin) |
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BoNTs are the most toxic proteins known. Encoded on the chromosome, plasmids and bacteriophage. Seven immunologically distinct forms of BoNT exist, designated as serotypes A to G. The subtypes can differ up to 36% on the amino acid level within a given serotype. So far, more than 40 subtypes have been described in the literature. BoNT/A, B, E, F induce botulism in humans, BoNT/C and D and their mosaic variants CD and DC induce botulism in animals, BoNT/G has not been clearly assigned to a natural outbreak in humans or animals. Additionally, several novel BoNT molecules have been pronounced: BoNT/HA (also called BoNT/FA or BoNT/H) which was involved in an infant botulism case and has been characterised as a novel mosaic type toxin and BoNT/X, both produced or encoded by C. botulinum, as well as eBoNT/J (aka BoNT/En) encoded by Enterococcus faecium. BoNTs associate with non-toxic clostridial proteins to form large, stable complexes that exist in cultures known as progenitor toxins. These progenitor toxins comprise three different forms: 12S (C 300 kDa), 16S (C 500 kDa), and 19S (C 900 kDa), and consist of neurotoxin subunits coupled with one or more non-toxic components known as neurotoxin associated proteins (NAPs). NAPs possess hemagglutinin activity (HA) protect the neurotoxin from harsh environment inside host like low pH and proteases, and include HA-17, HA-22, HA-33, and HA-55. ... |
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BoNT
(Botulinum neurotoxin) |
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BoNTs are the most toxic proteins known. Encoded on the chromosome, plasmids and bacteriophage. Seven immunologically distinct forms of BoNT exist, designated as serotypes A to G. The subtypes can differ up to 36% on the amino acid level within a given serotype. So far, more than 40 subtypes have been described in the literature. BoNT/A, B, E, F induce botulism in humans, BoNT/C and D and their mosaic variants CD and DC induce botulism in animals, BoNT/G has not been clearly assigned to a natural outbreak in humans or animals. Additionally, several novel BoNT molecules have been pronounced: BoNT/HA (also called BoNT/FA or BoNT/H) which was involved in an infant botulism case and has been characterised as a novel mosaic type toxin and BoNT/X, both produced or encoded by C. botulinum, as well as eBoNT/J (aka BoNT/En) encoded by Enterococcus faecium. BoNTs associate with non-toxic clostridial proteins to form large, stable complexes that exist in cultures known as progenitor toxins. These progenitor toxins comprise three different forms: 12S (C 300 kDa), 16S (C 500 kDa), and 19S (C 900 kDa), and consist of neurotoxin subunits coupled with one or more non-toxic components known as neurotoxin associated proteins (NAPs). NAPs possess hemagglutinin activity (HA) protect the neurotoxin from harsh environment inside host like low pH and proteases, and include HA-17, HA-22, HA-33, and HA-55. ... |
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BoNT
(Botulinum neurotoxin) |
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BoNTs are the most toxic proteins known. Encoded on the chromosome, plasmids and bacteriophage. Seven immunologically distinct forms of BoNT exist, designated as serotypes A to G. The subtypes can differ up to 36% on the amino acid level within a given serotype. So far, more than 40 subtypes have been described in the literature. BoNT/A, B, E, F induce botulism in humans, BoNT/C and D and their mosaic variants CD and DC induce botulism in animals, BoNT/G has not been clearly assigned to a natural outbreak in humans or animals. Additionally, several novel BoNT molecules have been pronounced: BoNT/HA (also called BoNT/FA or BoNT/H) which was involved in an infant botulism case and has been characterised as a novel mosaic type toxin and BoNT/X, both produced or encoded by C. botulinum, as well as eBoNT/J (aka BoNT/En) encoded by Enterococcus faecium. BoNTs associate with non-toxic clostridial proteins to form large, stable complexes that exist in cultures known as progenitor toxins. These progenitor toxins comprise three different forms: 12S (C 300 kDa), 16S (C 500 kDa), and 19S (C 900 kDa), and consist of neurotoxin subunits coupled with one or more non-toxic components known as neurotoxin associated proteins (NAPs). NAPs possess hemagglutinin activity (HA) protect the neurotoxin from harsh environment inside host like low pH and proteases, and include HA-17, HA-22, HA-33, and HA-55. ... |
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BoNT
(Botulinum neurotoxin) |
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BoNTs are the most toxic proteins known. Encoded on the chromosome, plasmids and bacteriophage. Seven immunologically distinct forms of BoNT exist, designated as serotypes A to G. The subtypes can differ up to 36% on the amino acid level within a given serotype. So far, more than 40 subtypes have been described in the literature. BoNT/A, B, E, F induce botulism in humans, BoNT/C and D and their mosaic variants CD and DC induce botulism in animals, BoNT/G has not been clearly assigned to a natural outbreak in humans or animals. Additionally, several novel BoNT molecules have been pronounced: BoNT/HA (also called BoNT/FA or BoNT/H) which was involved in an infant botulism case and has been characterised as a novel mosaic type toxin and BoNT/X, both produced or encoded by C. botulinum, as well as eBoNT/J (aka BoNT/En) encoded by Enterococcus faecium. BoNTs associate with non-toxic clostridial proteins to form large, stable complexes that exist in cultures known as progenitor toxins. These progenitor toxins comprise three different forms: 12S (C 300 kDa), 16S (C 500 kDa), and 19S (C 900 kDa), and consist of neurotoxin subunits coupled with one or more non-toxic components known as neurotoxin associated proteins (NAPs). NAPs possess hemagglutinin activity (HA) protect the neurotoxin from harsh environment inside host like low pH and proteases, and include HA-17, HA-22, HA-33, and HA-55. ... |
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BoNT
(Botulinum neurotoxin) |
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BoNTs are the most toxic proteins known. Encoded on the chromosome, plasmids and bacteriophage. Seven immunologically distinct forms of BoNT exist, designated as serotypes A to G. The subtypes can differ up to 36% on the amino acid level within a given serotype. So far, more than 40 subtypes have been described in the literature. BoNT/A, B, E, F induce botulism in humans, BoNT/C and D and their mosaic variants CD and DC induce botulism in animals, BoNT/G has not been clearly assigned to a natural outbreak in humans or animals. Additionally, several novel BoNT molecules have been pronounced: BoNT/HA (also called BoNT/FA or BoNT/H) which was involved in an infant botulism case and has been characterised as a novel mosaic type toxin and BoNT/X, both produced or encoded by C. botulinum, as well as eBoNT/J (aka BoNT/En) encoded by Enterococcus faecium. BoNTs associate with non-toxic clostridial proteins to form large, stable complexes that exist in cultures known as progenitor toxins. These progenitor toxins comprise three different forms: 12S (C 300 kDa), 16S (C 500 kDa), and 19S (C 900 kDa), and consist of neurotoxin subunits coupled with one or more non-toxic components known as neurotoxin associated proteins (NAPs). NAPs possess hemagglutinin activity (HA) protect the neurotoxin from harsh environment inside host like low pH and proteases, and include HA-17, HA-22, HA-33, and HA-55. ... |
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BoNT
(Botulinum neurotoxin) |
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BoNTs are the most toxic proteins known. Encoded on the chromosome, plasmids and bacteriophage. Seven immunologically distinct forms of BoNT exist, designated as serotypes A to G. The subtypes can differ up to 36% on the amino acid level within a given serotype. So far, more than 40 subtypes have been described in the literature. BoNT/A, B, E, F induce botulism in humans, BoNT/C and D and their mosaic variants CD and DC induce botulism in animals, BoNT/G has not been clearly assigned to a natural outbreak in humans or animals. Additionally, several novel BoNT molecules have been pronounced: BoNT/HA (also called BoNT/FA or BoNT/H) which was involved in an infant botulism case and has been characterised as a novel mosaic type toxin and BoNT/X, both produced or encoded by C. botulinum, as well as eBoNT/J (aka BoNT/En) encoded by Enterococcus faecium. BoNTs associate with non-toxic clostridial proteins to form large, stable complexes that exist in cultures known as progenitor toxins. These progenitor toxins comprise three different forms: 12S (C 300 kDa), 16S (C 500 kDa), and 19S (C 900 kDa), and consist of neurotoxin subunits coupled with one or more non-toxic components known as neurotoxin associated proteins (NAPs). NAPs possess hemagglutinin activity (HA) protect the neurotoxin from harsh environment inside host like low pH and proteases, and include HA-17, HA-22, HA-33, and HA-55. ... |
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BoNT
(Botulinum neurotoxin) |
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BoNTs are the most toxic proteins known. Encoded on the chromosome, plasmids and bacteriophage. Seven immunologically distinct forms of BoNT exist, designated as serotypes A to G. The subtypes can differ up to 36% on the amino acid level within a given serotype. So far, more than 40 subtypes have been described in the literature. BoNT/A, B, E, F induce botulism in humans, BoNT/C and D and their mosaic variants CD and DC induce botulism in animals, BoNT/G has not been clearly assigned to a natural outbreak in humans or animals. Additionally, several novel BoNT molecules have been pronounced: BoNT/HA (also called BoNT/FA or BoNT/H) which was involved in an infant botulism case and has been characterised as a novel mosaic type toxin and BoNT/X, both produced or encoded by C. botulinum, as well as eBoNT/J (aka BoNT/En) encoded by Enterococcus faecium. BoNTs associate with non-toxic clostridial proteins to form large, stable complexes that exist in cultures known as progenitor toxins. These progenitor toxins comprise three different forms: 12S (C 300 kDa), 16S (C 500 kDa), and 19S (C 900 kDa), and consist of neurotoxin subunits coupled with one or more non-toxic components known as neurotoxin associated proteins (NAPs). NAPs possess hemagglutinin activity (HA) protect the neurotoxin from harsh environment inside host like low pH and proteases, and include HA-17, HA-22, HA-33, and HA-55. ... |
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TeNT
(Tetanus neurotoxin) |
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BoNTs and TeNT share ~35% sequence identity. The BoNT catalytic LC domains share up to 36% sequence identity, and the LC domains of BoNT/B and TeNT have over 50% identity. ... |
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| Anthrax toxin |
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atxA, a pXO1 gene required for transcription of the three toxin genes, also positively regulated encapsulation. The expression of atxA gene is not controlled by CO2. ... |
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