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| Actin cross-linking domain (ACD)-containing toxin (total related VFs in database, current show from 1 to 2) |
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RtxA
(Repeat in toxin) |
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A member of a protein family that is produced by a wide range of Gram-negative bacteria, such as Vibrio cholerae, V. vulnificus, V. anguillarum, Actinobacillus actinomycetemcomitans, Actinobacillus pleuropneumoniae,etc. The rtx operon consists of six genes (rtxACHBDE) in which rtxA encodes an exotoxin, rtxC codes for an RtxA activator, rtxH encodes a conserved hypothetical protein and rtxBDE genes code for an ABC transporter. Important characteristics of this toxin include:. I) it requires post-translational modification, i.e., acylation to become biologically active. II) has a COOH-terminal calcium-binding domain with tandem glycine/aspartic acid-rich repeats. III) it has a high molecular mass of usually 100 to >400 kDa. IV) it is delivered to the extracellular milieu through the T1SS. ... |
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RtxA
(Repeat in toxin) |
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A member of a protein family that is produced by a wide range of Gram-negative bacteria, such as Vibrio cholerae, V. vulnificus, V. anguillarum, Actinobacillus actinomycetemcomitans, Actinobacillus pleuropneumoniae,etc. The rtx operon consists of six genes (rtxACHBDE) in which rtxA encodes an exotoxin, rtxC codes for an RtxA activator, rtxH encodes a conserved hypothetical protein and rtxBDE genes code for an ABC transporter. Important characteristics of this toxin include:. I) it requires post-translational modification, i.e., acylation to become biologically active. II) has a COOH-terminal calcium-binding domain with tandem glycine/aspartic acid-rich repeats. III) it has a high molecular mass of usually 100 to >400 kDa. IV) it is delivered to the extracellular milieu through the T1SS. ... |
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