Catechol-based siderophore. Disruption of the siderophore bacillibactin production drastically reduces the ability of B. cereus to utilize ferritin for growth and results in attenuated bacterial virulence in insects. ...
An extremely effective iron chelator, with a formation constant for the iron complex of 1049. Fe3+ is coordinated by six catechol oxygens to form a metal chelate with a net negative charge of three. ...
Aer is typically plasmid-encoded. The siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae. ...
Salmochelin is a glycosylated Ent that requires the iroA locus for production and transport. A major trigger of inflammation and bacterial dissemination induced during K. pneuminiae lung infection. ...
Ybt is the most common virulence factor associated with human K. pneumoniae infections. The phenolate siderophore Ybt contributes to evasion of the activity of lipocalin2 in the lung – a host factor which neutralizes enterobactin-based iron acquisition. ...