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| MgtC |
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Homology to MgtC of Salmonella enterica, which is essential for the survival of S.enterica within macrophages. ... |
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| Nitrate reductase |
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NarX function as a respiratory fused nitrate reductase (three different domains present in this protein encode the difference subunits of nitrate reductase: the N-terminal domain showing similarity to narG, the central domain showing homology with narJ and the C-terminus showing homology to narI). NarGHJI is a membrane-bound nitrate reductase complex. NarK2, a putative nitrite-extrusion protein. ... |
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| PanC/PanD |
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Lipid biosynthesis and metabolism play a pivotal role in the intracellular replication and persistence of M. tuberculosis. Pantothenic acid (vitamin B5) is an essential molecule required for the synthesis of coenzyme A and acyl carrier protein (ACP). PanC (pantothenate synthetase) and PanD (aspartate-1-decarboxylase) involved in pantothenate biosynthesis. ... |
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| FbpABC |
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Encodes a periplasmic-binding protein-dependent iron transport system necessary for the utilization of iron bound to transferrin or iron chelates, FbpA is the periplasmic Fe3+ binding protein. ... |
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| HmbR |
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The gene encoding the hemoglobin receptor, hmbR, is located downstream of a gene involved in the catabolism of heme, hemO. Expression of HmbR undergoes phase variation due to slip-strand mispairing of poly(G) tracts within the hmbR gene. The advantage associated with phase-varying surface proteins is evasion of the host immune response. ... |
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| HpuAB |
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Expression of HpuAB undergoes phase variation due to slip-strand mispairing of poly(G) tracts within the hpuA gene. ... |
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Lbp
(Lactoferrin-binding protein) |
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The entry site of N. meningitidis into the body is the nasopharynx, where lactoferrin predominates as the main source of iron. ... |
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Tbp
(Transferrin-binding protein) |
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The tbp locus is a bicistronic operon consisting of tbpA and tbpB. Unlike the case for many other genes of Neisseria, there is no phase variation of the transferrin receptor. ... |
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| MgtBC |
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Hypothesized to be a magnesium transporter. MgtA and MgtB are not required for intracellular survival or for virulence, MgtC is essential for both functions. ... |
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PsaA
(Pneumococcal surface antigen A) |
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Surface protein: lipid-attached. AdcABC is another ABC transporter for Zn2+ uptake. ... |
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