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BslA
(B. anthracis S-layer protein A) |
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Consists of a canonical Ig-like domain, to which is appended a three-stranded "cap" that is highly hydrophobic in character, rich in leucine residues as well as isoleucine, valine, and alanine. This cap comprises a surface-exposed hydrophobic patch. ... |
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| Quorum-sensing |
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CepIR is the ancestral quorum-sensing system in the Burkholderia genus, BspIR is homolgous to CepIR in B. pseudomallei.. B. pseudomallei encodes three AHL synthases, encoded by bpsI1, bpsI2 and bpsI3, and five regulator genes. ... |
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| CD2831 |
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Cell surface protein cleaved and covalently anchored to m-DAP in the peptidoglycan by SrtB. A collagen-binding protein contributing to C. difficile adhesion to the host ECM. May play a role in biofilm formation. Binds to human complement C1q and thus potentially be involved in host immune evasion mechanisms. Important in early biofilm formation. ... |
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| CD3246 |
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Cell surface protein cleaved and covalently anchored to m-DAP in the peptidoglycan by SrtB. Belongs to a group of bacterial proteins containing an internal thioester. Members of this family of proteins mediate covalent attachment to host proteins, resulting in firm attachment. ... |
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| BopD |
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Homologous to a sugar-binding transcriptional regulator involved in biofilm production. The actual role is unknown, but the association of enhanced biofilm formation in the presence of glucose and the possible involvement of a sugar-binding transcriptional regulator suggest a linkage to increased biofilm production in E. faecalis in the presence of specific carbohydrates. ... |
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Fsr
(E. faecalis regulator) |
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The fsrABC operon is homologus to agrABCD in Staphylococcus aureus. The lack of an AgrD homologue is consistent with the exquisite specificity seen with autoinducing polypeptides quorum sensing systems for each species and subspecies. ... |
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| Quorum sensing |
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Consists of two separate but interrelated systems, las and rhl. The autoinducer signal molecules produced by P.aeruginosa are N-(3-oxododencanoyl) homeserine lactone(3O-C12-HSL) and N-butyryl homoserine lactone(C4-HSL). A novel, additional autoinducer has recently been demonstrated to be involved in quorum sensing. It is 2-heptyl-3-hydroxy-4-quinolone, an additional link between the Las and Rhl circuits. ... |
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| Rhamnolipid |
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Nonenzyme glycolipid. Mainly acylated rhamnose moieties synthesized by four enzymes using substrates derived from fatty acid biosynthesis and thymidine-diphospho-L-rhamnose. ... |
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IcsA (VirG)
(Ics for intercellular spread) |
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Three distinctive domains: the N-terminal signal sequence (1-52), the 706 α-domain (53-758), the 344 C-terminal β-core. β-core embedded in the outer membrane, the C-terminal ~220 aa of IcsAα (509-729) are essential for the unipolar distribution of IcsA, the residues (103-433) are the binding site for N-WASP. residues (53-506) is the region of vinculin interaction and is essential for F-actin assembly. ... |
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AI-2
(Autoinducer-2) |
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AI-2 is produced and detected by a wide variety of bacteria and is presumed to facilitate interspecies communications. ... |
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