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VF category: Complement evasion/Serum resistance (total 201 related VFs in database, current show from 1 to 10)
 
VF Bacteria Brief description
PbpG
(Penicillin-binding protein)
Acinetobacter
(A. baumannii ACICU)
 Penicillin-binding proteins (PBPs) are most commonly associated with binding to and inactivating b-lactam antibiotics. PBPs also participate in the final steps of the biosynthesis of the peptidoglycan layer and thus contribute to bacterial cell stability. ...
Brk
(Bordetella resistance to killing)
Bordetella
(B. pertussis Tohama I)
 The brk locus was also found in B. parapertussis and B. bronchiseptica but not B. avium. ...
fHbp
Neisseria
(N. meningitidis MC58)
 PDB code: 3KVD. Binds complment factor H to prevent complement-mediated killing. ...
NspA
(Neisserial surface protein A)
Neisseria
(N. meningitidis MC58)
 PDB code: 1P4T. Binds complement factor H to inhibit host innate immune defenses. ...
Adr1
(Adhesion of Rickettsiae protein 1)
Rickettsia
(R. typhi str. Wilmington)
 An integral outer-membrane protein containing eight membrane-embedded β-strands and four "loop" regions that are exposed to extracellular milieu. Belongs to a family of gram-negative outer membrane proteins embodied by E. coli OmpX. Some members of this protein family, namely Yersinia enterolitica Ail and Salmonella typhimurium Rck. ...
Adr2
(Adhesion of Rickettsiae protein 2)
Rickettsia
(R. typhi str. Wilmington)
 In all Rickettsia genomes, two Adr paralogs are encoded adjacent to one another and share ~45% aa identity. ...
Rck
(Resistance to complement killing)
Salmonella
(S. enterica subsp. enterica serovar Typhimurium str. LT2)
 Rck belongs to a family of five homologous OMP proteins characterized in Salmonella (Rck and PagC), Escherichia coli (Lom), Yersinia enterocolitica (Ail) and Enterobacter cloacae (OmpX). ...
Sbi
(Staphylococcal binder of immunoglobulin)
Staphylococcus
(S. aureus subsp. aureus MW2)
 A secreted protein that is also associated with the bacterial envelope, lacks a C-terminal LPXTG sorting signal. ...
SCIN
(Staphylococcal complement inhibitor)
Staphylococcus
(S. aureus subsp. aureus MW2)
 Located on the β-hemolysin (hlb)-converting bacteriophages. Evasion from innate immunity. ...
β-C protein
Streptococcus
(S. agalactiae FM027022)
 Streptococcal surface protein, no long repeats, C-terminal a proline-rich region adopts the conformation of a left-handed polyproline II (PPII) helix, an extended and solvent-exposed structure. ...
   


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