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theta-toxin/PFO
(Perfringolysin O) |
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PFO is cholesterol-dependent cytolysin (CDC) belonging to the superfamily of β pore-forming toxins. The toxins are produced as soluble monomers that bind to cell membranes via their respective receptors and oligomerize into pore-forming complexes. CDC oligomers are comprised of up to 50 monomers and form an unusually large pore (25-30nm in diameter). ... |
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theta-toxin/PFO
(Perfringolysin O) |
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PFO is cholesterol-dependent cytolysin (CDC) belonging to the superfamily of β pore-forming toxins. The toxins are produced as soluble monomers that bind to cell membranes via their respective receptors and oligomerize into pore-forming complexes. CDC oligomers are comprised of up to 50 monomers and form an unusually large pore (25-30nm in diameter). ... |
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theta-toxin/PFO
(Perfringolysin O) |
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PFO is cholesterol-dependent cytolysin (CDC) belonging to the superfamily of β pore-forming toxins. The toxins are produced as soluble monomers that bind to cell membranes via their respective receptors and oligomerize into pore-forming complexes. CDC oligomers are comprised of up to 50 monomers and form an unusually large pore (25-30nm in diameter). ... |
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theta-toxin/PFO
(Perfringolysin O) |
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PFO is cholesterol-dependent cytolysin (CDC) belonging to the superfamily of β pore-forming toxins. The toxins are produced as soluble monomers that bind to cell membranes via their respective receptors and oligomerize into pore-forming complexes. CDC oligomers are comprised of up to 50 monomers and form an unusually large pore (25-30nm in diameter). ... |
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| Cytolysin |
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Production and activation of cytolysin involves the products of a complex operon of eight genes and that this operon can be located on either pheromone-responsive plasmids or on the chromosome within a pathogenicity island. Most of this gene locus is absent in E. faecalis V583 due to a 17-kbp deletion. Cytolysin expression is regulated by one of the subunits (CylLS'') through a quorum-sensing autoinduction mechanism. ... |
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| α-Hemolysin |
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Best-characterized RTX protein secreted by a type I secretion system: the structural gene encoding the hemolysin (hlyA) is part of an operon that also encodes a dedicated export system (HlyB and HlyD comprising a type I secretion system) and a toxin modifying enzyme (HlyC). The HlyC protein is responsible for acylation of HlyA, resulting in toxin activation. The hly operon is found on a plasmid of EHEC O157:H7, while the hly operon is often located adjacent to the P fimbrial genes on the same pathogenicity island on the chromosome of UPEC strains. ... |
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| α-Hemolysin |
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Best-characterized RTX protein secreted by a type I secretion system: the structural gene encoding the hemolysin (hlyA) is part of an operon that also encodes a dedicated export system (HlyB and HlyD comprising a type I secretion system) and a toxin modifying enzyme (HlyC). The HlyC protein is responsible for acylation of HlyA, resulting in toxin activation. The hly operon is found on a plasmid of EHEC O157:H7, while the hly operon is often located adjacent to the P fimbrial genes on the same pathogenicity island on the chromosome of UPEC strains. ... |
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| α-Hemolysin |
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Best-characterized RTX protein secreted by a type I secretion system: the structural gene encoding the hemolysin (hlyA) is part of an operon that also encodes a dedicated export system (HlyB and HlyD comprising a type I secretion system) and a toxin modifying enzyme (HlyC). The HlyC protein is responsible for acylation of HlyA, resulting in toxin activation. The hly operon is found on a plasmid of EHEC O157:H7, while the hly operon is often located adjacent to the P fimbrial genes on the same pathogenicity island on the chromosome of UPEC strains. ... |
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| Hemolysin |
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Best-characterized RTX protein secreted by a type I secretion system: the structural gene encoding the hemolysin (hlyA) is part of an operon that also encodes a dedicated export system (HlyB and HlyD comprising a type I secretion system) and a toxin modifying enzyme (HlyC). The HlyC protein is responsible for acylation of HlyA, resulting in toxin activation. The hly operon is found on a plasmid of EHEC O157:H7, while the hly operon is often located adjacent to the P fimbrial genes on the same pathogenicity island on the chromosome of UPEC strains. ... |
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| Hemolysin |
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Best-characterized RTX protein secreted by a type I secretion system: the structural gene encoding the hemolysin (hlyA) is part of an operon that also encodes a dedicated export system (HlyB and HlyD comprising a type I secretion system) and a toxin modifying enzyme (HlyC). The HlyC protein is responsible for acylation of HlyA, resulting in toxin activation. The hly operon is found on a plasmid of EHEC O157:H7, while the hly operon is often located adjacent to the P fimbrial genes on the same pathogenicity island on the chromosome of UPEC strains. ... |
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