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theta-toxin/PFO
(Perfringolysin O) |
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PFO is cholesterol-dependent cytolysin (CDC) belonging to the superfamily of β pore-forming toxins. The toxins are produced as soluble monomers that bind to cell membranes via their respective receptors and oligomerize into pore-forming complexes. CDC oligomers are comprised of up to 50 monomers and form an unusually large pore (25-30nm in diameter). ... |
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theta-toxin/PFO
(Perfringolysin O) |
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PFO is cholesterol-dependent cytolysin (CDC) belonging to the superfamily of β pore-forming toxins. The toxins are produced as soluble monomers that bind to cell membranes via their respective receptors and oligomerize into pore-forming complexes. CDC oligomers are comprised of up to 50 monomers and form an unusually large pore (25-30nm in diameter). ... |
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theta-toxin/PFO
(Perfringolysin O) |
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PFO is cholesterol-dependent cytolysin (CDC) belonging to the superfamily of β pore-forming toxins. The toxins are produced as soluble monomers that bind to cell membranes via their respective receptors and oligomerize into pore-forming complexes. CDC oligomers are comprised of up to 50 monomers and form an unusually large pore (25-30nm in diameter). ... |
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| Cytolysin |
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Production and activation of cytolysin involves the products of a complex operon of eight genes and that this operon can be located on either pheromone-responsive plasmids or on the chromosome within a pathogenicity island. Most of this gene locus is absent in E. faecalis V583 due to a 17-kbp deletion. Cytolysin expression is regulated by one of the subunits (CylLS'') through a quorum-sensing autoinduction mechanism. ... |
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| α-Hemolysin |
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Best-characterized RTX protein secreted by a type I secretion system: the structural gene encoding the hemolysin (hlyA) is part of an operon that also encodes a dedicated export system (HlyB and HlyD comprising a type I secretion system) and a toxin modifying enzyme (HlyC). The HlyC protein is responsible for acylation of HlyA, resulting in toxin activation. The hly operon is found on a plasmid of EHEC O157:H7, while the hly operon is often located adjacent to the P fimbrial genes on the same pathogenicity island on the chromosome of UPEC strains. ... |
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| α-Hemolysin |
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Best-characterized RTX protein secreted by a type I secretion system: the structural gene encoding the hemolysin (hlyA) is part of an operon that also encodes a dedicated export system (HlyB and HlyD comprising a type I secretion system) and a toxin modifying enzyme (HlyC). The HlyC protein is responsible for acylation of HlyA, resulting in toxin activation. The hly operon is found on a plasmid of EHEC O157:H7, while the hly operon is often located adjacent to the P fimbrial genes on the same pathogenicity island on the chromosome of UPEC strains. ... |
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| α-Hemolysin |
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Best-characterized RTX protein secreted by a type I secretion system: the structural gene encoding the hemolysin (hlyA) is part of an operon that also encodes a dedicated export system (HlyB and HlyD comprising a type I secretion system) and a toxin modifying enzyme (HlyC). The HlyC protein is responsible for acylation of HlyA, resulting in toxin activation. The hly operon is found on a plasmid of EHEC O157:H7, while the hly operon is often located adjacent to the P fimbrial genes on the same pathogenicity island on the chromosome of UPEC strains. ... |
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| Heat-stable toxin (ST) |
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STs are small, single-peptide toxins that include two unrelated classes: STa and STb, which differ in both structure and mechanism of action. Only toxins of the STa class have been associated with human disease. The STb toxin is associated with animal disease. ... |
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| Hemolysin |
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Best-characterized RTX protein secreted by a type I secretion system: the structural gene encoding the hemolysin (hlyA) is part of an operon that also encodes a dedicated export system (HlyB and HlyD comprising a type I secretion system) and a toxin modifying enzyme (HlyC). The HlyC protein is responsible for acylation of HlyA, resulting in toxin activation. The hly operon is found on a plasmid of EHEC O157:H7, while the hly operon is often located adjacent to the P fimbrial genes on the same pathogenicity island on the chromosome of UPEC strains. ... |
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| Hemolysin |
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Best-characterized RTX protein secreted by a type I secretion system: the structural gene encoding the hemolysin (hlyA) is part of an operon that also encodes a dedicated export system (HlyB and HlyD comprising a type I secretion system) and a toxin modifying enzyme (HlyC). The HlyC protein is responsible for acylation of HlyA, resulting in toxin activation. The hly operon is found on a plasmid of EHEC O157:H7, while the hly operon is often located adjacent to the P fimbrial genes on the same pathogenicity island on the chromosome of UPEC strains. ... |
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