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T7SS
(Type VII secretion system) |
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Type VII systems are present in both pathogenic and nonpathogenic species of Bacillus. In the model organism B. subtilis, the core functional components of an ESX secretion system are encoded by the yuk/yue locus that contains yukE, yukD, yukC, yukBA, yueB, and yueC. ... |
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ESX-1
(ESAT-6 secretion system-1) |
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The ESX-1 secretion system is encoded by two different loci, the ESX-1 locus and the EspA operon. The exact number of components that are involved in ESX-1 secretion is still debated and seems to vary between different mycobacterial species. All the known ESX-1 substrates, Rv3616c(EspA), Rv3615c, ESAT-6 and CFP-10 are mutually dependent on each other for secretion. ... |
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| ESX-3 |
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Required for siderophore-mediated iron acquisition. ... |
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ESX-5
(ESAT-like secretion system) |
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Essential for the secretion of the ESX-5-encoded ESAT-6-family member EsxN by M. marinum. Necessary and sufficient to produce a functional secretion machinery for PPE41 in M. smegmatis. ... |
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| Type VII secretion system |
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At the molecular level, the S. aureus T7SS is composed of four membrane-associated proteins (EsaA, EssA, EssB, and EssC), three soluble cytosolic proteins (EsaB, EsaE, and EsaG), and five secreted virulence factors (EsxA, EsxC, EsxB, EsxD, and EsaD). ... |
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| CpnT |
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Secreted by ESX-5. CpnT is a two-domain protein in which the toxic activity resides in the C-terminus. ... |
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ESAT-6/CFP-10
(Early secretory antigenic target of 6 kDa/culture filtrate protein of 10 kDa) |
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Secreted protein. ESAT-6 and CFP-10 proteins are cotranscribed and form a tight 1:1 complex. A striking feature of the CFP-10/ESAT-6 complex is the long flexible arm formed by the C-terminus of CFP-10, which is essential for binding to the surface of cells. PDB code:1wa8. ... |
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| EsxG-EsxH |
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EsxG-EsxH heterodimer is secreted by ESX-3. EsxG-EsxH heterodimer of M. tuberculosis can inhibit host endosomal sorting complex required for transport (ESCRT) machinery, raising the possibility that M. tuberculosis impairs this host response. EsxG-EsxH also facilitated secretion of several members of the proline-glutamic acid (PE) and proline-proline-glutamic acid (PPE) protein families that play roles in iron acquisition. ... |
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T7SS
(Type VII secretion system) |
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Type VII systems are present in both pathogenic and nonpathogenic species of Bacillus. In the model organism B. subtilis, the core functional components of an ESX secretion system are encoded by the yuk/yue locus that contains yukE, yukD, yukC, yukBA, yueB, and yueC. ... |
|
T7SS
(Type VII secretion system) |
|
Type VII systems are present in both pathogenic and nonpathogenic species of Bacillus. In the model organism B. subtilis, the core functional components of an ESX secretion system are encoded by the yuk/yue locus that contains yukE, yukD, yukC, yukBA, yueB, and yueC. ... |
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