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| T2SS |
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Although the T2SS machinery is conserved across Acinetobacter spp., the effector repertoire is diverse and varies from strain to strain. Secretion of type II effectors, CpaA and LipA, require specific membrane-associated chaperones, CpaB and LipB. ... |
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| Exe T2SS |
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Essential for secretion of many virulence factors, such as aerolysin, proteases, haemolysin and DNase. ... |
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lsp T2SS
(Type II secretion system) |
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This secretion system is encoded on 5 regions scattered over the chromosome in contrast to most other bacteria where the type II genes are clustered in one or two regions. ... |
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| xcp secretion system |
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Secretes toxins and enzymes into the extracellular fluid. Need for proper localization of PilB and PilC. ... |
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T2SS
(Type II secretion system) |
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T2SS encoded by genes of the general secretion pathway (gsp) is widely distributed in Gram-negative bacteria. The known E.coli T2SS, responsible for chitinase secretion, encoded by the yhe genes at 74.5 min of the MG1655 chromosome is absent in all four sequenced Shigella genomes. A novel set of gsp genes are located on the S. dysenteriae Sd197 and S. boydii Sb227 chromosomes. The Sb227 T2SS is likely to be inactive due to a frameshift in gspC and a nonsense mutation in gspD. Those genes show significant similarity to those from ETEC and Vibrio cholerae responsible for secreting the E.coli heat labile toxin (Ltx) and cholera toxin (Ctx), respectively. While Shiga toxin has an overall similar structure to Ctx and Ltx. ... |
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Eps T2SS
(Extracellular protein secretion) |
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V. cholerae causes diarrhea by T2SS-dependent secretion of cholera toxin. V. cholerae exports, via the T2SS, other extracellular factors, including chitinases, proteases, DNase, and pilin, which aid in its ability to successfully occupy diverse ecological niches. Eps T2SS also secretes the three proteins RbmA, RbmC, and Bap1, which are necessary for robust, shear-resistant biofilm formation. ... |
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Yst1 T2SS
(Yst1 type II secretion system) |
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The Yts1 T2SS seems to be present in all high-pathogenicity Y. enterocolitica species (serotypes O:8, O:13, O:20, O:21) but not in low-pathogenic Y. enterocolitica isolates (e.g., O:3, O:9). ... |
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CpaA
(Coagulation targeting metallo-endopeptidase of A. baumannii) |
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CpaA is the best characterized and most abundant effector secreted by several medically relevant Acinetobacter strains. CpaA stability and secretion depend on the membrane-bound chaperone CpaB, which is encoded adjacent to CpaA. ... |
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| Heat-labile toxin (LT) |
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Secreted to the extracellular milieu by a type II secretion system. LT-I is plasmid-encoded. LT-II only produced by strains isolated from animals. ... |
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StcE
(Secreted protease of C1 esterase inhibitor from EHEC) |
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Encoded within the pO157 plasmid that belongs to the family of serine protease inhibitor. Secreted by a type II secretory apparatus also encoded within pO157 plasmid and is transcriptionally activated by the Ler, so the production of StcE is coupled with activation of the LEE genes. ... |
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