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OmpA
(Outer membrane protein A) |
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Major outer membrane protein in E. coli, homologous to Neisseria Opa proteins which have been shown to be involved in invasion of eukaryotic cells. ... |
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| TraJ |
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Belongs to a cluster of genes within the F-like plasmid R1-19 transfer region called the tra operon. Homology with a component of the bacterial conjugation system. ... |
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| Auto |
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A surface protein in L. monocytogenes but absent in L. innocua. The aut gene is expressed independently of PrfA. ... |
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InlA
(Internalin A) |
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An acidic protein of 800 amino acids, N-terminal 15 leucine-rich repeat (LRR) region, followed by conserved the inter-repeat (IR) region. C-terminus comprises two and a half repeats of 75 amino acids, followed by a region that contains an Leu-Pro-X-Thr-Gly (LPXTG) motif that allows covalent linkage of the protein to the peptidoglycan. PDB code: 1O6S. ... |
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InlB
(Internalin B) |
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N-terminal 8 LRR region, followed by the conserved inter-repeat (IR) region. C domain consisting of tandemly arranged 80-amino acids repeats starting with the sequence GW(dipeptide Gly-Trp), which uses lipoteichoic acid as ligand and mediates a loose attachment of the protein to the bacterial surface. PDB code :1M9S. ... |
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LpeA
(Lipoprotein promoting entry) |
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Membrane protein homologous to a Streptococcus pneumoniae adherence factor PsaA, but LpeA is not involved in adhesion. The only listerial lipoprotein known to date to be involved in invasion. ... |
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| p60 |
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Encoded by the iap (for invasion-associated protein) gene. Not regulated by PrfA. A modular protein containing two LysM domains, a bacterial Src homology 3 (SH3) domain and a C-terminal NLPC/P60 domain. The LysM domain is involved in degradation of bacterial cell wall. The function of SH3 domain is as yet unknown, but it may probably mediate interaction with host signalling molecules. ... |
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Vip
(Virulence protein) |
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A LPXTG protein anchored to the peptidoglycan by SrtA. Interacts with Gp96 localized at the surface of host cells during invasion and that this interaction is critical for a successful infection in vivo. ... |
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Opa
(Opacity-associated) |
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Opa proteins were originally identified because their expression changes the color and opacity of colonies. The effect may be due to an increased interbacterial aggregation that results from the lectin-like ability of Opa proteins to bind to LOS on adjacent bacteria. A single gonococcal strain can harbor up to 12 opa genes, meningococci usually encode 3 to 4 Opa proteins. All opa genes sequenced to date contain 5' tandem repeats [CTCTT]n that cause high-frequency phase variable expression. Grouped into two major classes according to the binding specificity for human surface receptors: the OpaHS-type (heparansulphate proteoglycan (HSPG) and OpaCEA-type (carcinoembryonic antigen (CEA) or related molecules). ... |
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| Opc |
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A beta barrel protein with five surface loops encoded by a single gene. Phase-variable expression of the meningococal Opc is mediated by slip-strand errors in a homopolymeric cytidine tract residing within the promoter of the opc gene. ... |
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