Human Immunodeficiency Virus (HIV)
Our HIV/AIDS research programs touch various aspects of viral infection and pathogenesis, immunologic mechanism and vaccine development. In particular, the programs include viral membrane fusion mechanism and entry inhibitors, viral replication and assembly, virus-host interaction and antiviral restriction factors, as well as mucosal immunity, neutralizing antibodies, vaccine antigen screen and design.
HIV entry pathway
Hepatitis B Virus (HBV) & Hepatitis C Virus (HCV)
The HBV projects focus on the pathogenesis of chronic infection, including mechanisms of HBsAg phagocytosis and antigen presentation, screening of human neutralizing monoclonal antibodies and development of a new therapeutic vaccine.
The HCV projects focus on the pathogenesis, diagnosis, prevention and therapy of hepatitis C virus (HCV) infection, including identification and characterization of virus receptors, host factors involved in virus replication, screening of serum biomarkers and association with disease progression.
HBV infection
Influenza Virus
Research on influenza virus mainly focuses on understanding the molecular mechanisms of viral replication strategies and host antiviral responses, including molecular interactions between influenza virus and the host cell, structural and functional analysis of the influenza virus RNA polymerase and implications for host range restriction and virus pathogenicity, molecular mechanisms of host innate immunity and inflammatory reactions, as well as development of antiviral technologies such as viral diagnosis, vaccine and RNA interference.
Structure of influenza virus
Studies are mainly focusing on etiology and molecular epidemiology of hand-foot-and-mouth disease (HFMD) caused by Enterovirus 71 (EV71), structures of both host factors associated with virus replication and viral virulence factors, pathogenesis and host-virus interaction, mechanism that virus regulates host immunity and inflammatory reaction, antivirus technologies such as molecular markers in disease progression and RNA interference.
Molecular structure of EV71 3C protein
Rhinovirus and Other Major Respiratory Viruses
This program focuses on etiology, molecular evolution and pathogenesis of new emerging respiratory viruses, including molecular epidemiology and molecular evolution of viruses, identification of unknown viruses, viral receptor and host immune responses, pathogenesis of emerging respiratory viruses, and high-throughput screening technology for virus.
Rhinovirus particle
Mycobacterium tuberculosis
Research projects are concentrating on screening of mutations associated with drug-resistance, anti-bacterium molecules, mapping antigen epitopes and studying pathogenic mechanism and infection-induced immunity to M. tuberculosis.
M. tuberculosis
Current project focuses on pathogenesis, epidemiology and molecular evolution of Shigella (particularly on S. flexneri 2a and S. sonnei), by use of a variety of modern technologies, including genomics, comparative genomics, transcriptomics, proteomics, RNAomics, and metabonomics etc.
Genomics and transcriptomics of S. flexneri 2a strain 301
Neisseria meningitidis
Studies are focusing on molecular epidemiology of Neisseria meningitidis, bacterial genomics and comparative genomics, molecular evolution, transcriptome with particular interests in small non-coding RNAs and their regulatory mechanism.
Molecular epidemiology of N. meningitidis in China
Trichophyton rubrum
Studies in this area are focusing on genome-wide transcription variation in Trichophyton rubrum with or without drug pressure for identification of potential drug targets and virulence factors. The aim is to understand mechanisms of gene regulation and pathogenesis.
cDNA microarray and expression profile of T. rubrum
Schistosoma japonicum
The research project is focusing on the biology and pathogenesis of Schistosoma japonicum and related schistosomiasis, especially on genome-wide transcription and regulation mechanisms in parasite development. The aim is to target parasite antigens associated with host immunopathogenesis and immune protection.
RNA-sequencing of S. japonicum
Studies are focusing on the identification of protective antigens and techniques for parasite differentiation and diagnosis with the aim to understand malaria pathogenesis of P. falciparum, P. vivax, and P. knowlesi.
Plasmodium infection model
Scientific publications - [2017] [2016] [2015] [2014] [2013] [2012] [2011] [2010] [2009] [2008]