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Compound category: Benzene and substituted derivatives
(total 5 related compounds in database)
 
Compound name 2D structure Target pathogen(s) Related VF/VFcategory Max phase Reference(s)
Fluorothiazinon Depiction based on curated SMILES OH O S F F H 3 C NH O N N O Acinetobacter
Chlamydia
Klebsiella
Pseudomonas
Salmonella		 Biofilm
TTSS (Type III secretion system)
Biofilm
TTSS (Type III secretion system)
TTSS (SPI-1 encode); TTSS (SPI-2 encode)		 Preclinical (in vivo)
Preclinical (in vivo)
Preclinical (in vitro)
Preclinical (in vivo)
Phase II trial		 Bondareva NE, et al. 2022. J Antibiot (Tokyo)
Zigangirova NA, et al. 2012. Acta Naturae; Koroleva EA, et al. 2015. Biomed Res Int; Zigangirova NA, et al. 2016. J Med Microbiol
Tsarenko SV, et al. 2023. J Antibiot (Tokyo)
Sheremet AB, et al. 2018. Biomed Res Int
Nesterenko LN, et al. 2016. J Antibiot (Tokyo); Zigangirova NA, et al. 2021. J Antibiot (Tokyo)
1-(3-chlorophenyl)-3-[(3,4,5-trimethoxybenzoyl)amino]urea Depiction based on curated SMILES CH 3 O CH 3 O Cl CH 3 N H O N H HN O O Acinetobacter Biofilm Preclinical (in vitro) Sambanthamoorthy K, et al. 2015. Bioorg Med Chem Lett
N-ethyl-2-[(3,4,5-trimethoxyphenyl)carbonyl]hydrazinecarbothioamide Depiction based on curated SMILES H 3 C O H 3 C O H 3 C O CH 3 O N H NH S N H Acinetobacter Biofilm Preclinical (in vitro) Sambanthamoorthy K, et al. 2015. Bioorg Med Chem Lett
1-tert-butyl-3-[(3,4,5-trimethoxybenzoyl)amino]thiourea Depiction based on curated SMILES CH 3 O CH 3 O CH 3 O H 3 C O HN NH S HN CH 3 CH 3 Acinetobacter Biofilm Preclinical (in vitro) Sambanthamoorthy K, et al. 2015. Bioorg Med Chem Lett
3-cyclopropyl-5-(trifluoromethyl)-1-(3,4,5-trimethoxybenzoyl)-4,5-dihydro-1H-pyrazol-5-ol Depiction based on curated SMILES O HO F F F N N H 3 C H 3 C O CH 3 O O Acinetobacter Biofilm Preclinical (in vitro) Sambanthamoorthy K, et al. 2015. Bioorg Med Chem Lett
   
   
   
   
   
   
   
   
   
   
   


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