Pht (phagosomal transporter)
Related genes: phtA;
Keywords: Nutrient acquisition; Transporter;
Functions:
Enables transmissive L. pneumophila to assess their phagosomal nutrient supply before reentering the cell cycle
Mechanism:
PhtA contains 12 transmembrane domains characteristic of the Major Facilitator Superfamily (MFS) of transporters, was shown to transport threonine, an essential amino acid fro L. pneumophila maturation to the replicative phase
References:
Sauer JD, et al., 2005. The phagosomal transporter A couples threonine acquisition to differentiation and replication of Legionella pneumophila in macrophages. Proc. Natl. Acad. Sci. USA. 102(28):9924-9929.

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