Related genes: rtxA;
Keywords: Toxin; Membrane-damaging; Pore-forming toxin; Functions: Potent host cell cytolysin, the 'cytolysin/egress pore' is essential for lysis of the host cell from within the phagosome to allow the bacteria to exit.
References: Cirillo SL, et al., 2001. Legionella pneumophila entry gene rtxA is involved in virulence. Infect. Immun. 69(1):508-517.
D'Auria G, et al., 2008. Virulence factor rtx in Legionella pneumophila, evidence suggesting it is a modular multifunctional protein. BMC Genomics 9:14.