ClpC
Related genes: clpC;
Keywords: Stress protein;
Characteristics:
 27-kDa stress protein belongs to the Hsp100/Clp family
Regulation of Clp protease expression is mediated by CtsR, the product of the first gene in the ClpC operon
Functions:
An ATPase promoting early escape form the phagosome of macrophages
ClpC is also required for adhesion and invasion, possibly by modulating the expression of InlA,InlB and ActA
References:
 Rouquette C, et al., 1996. Identification of a ClpC ATPase required for stress tolerance and in vivo survival of Listeria monocytogenes. Mol. Microbiol. 21(5):977-987.
Rouquette C, et al., 1998. The ClpC ATPase of Listeria monocytogenes is a general stress protein required for virulence and promoting early bacterial escape from the phagosome of macrophages. Mol. Microbiol. 27(6):1235-1245.
Nair S, et al., 2000. ClpC ATPase is required for cell adhesion and invasion of Listeria monocytogenes. Infect. Immun. 68(12):7061-7068.
ClpE
Related genes: clpE;
Keywords: Stress protein;
Characteristics:
Belongs to HSP-100/Clp family
Functions:
An ATPase required for prolonged survival at 42 degree
Acts synergistically with ClpC in cell division
References:
Nair S, et al., 1999. ClpE, a novel member of the HSP100 family, is involved in cell division and virulence of Listeria monocytogenes. Mol. Microbiol. 31(1):185-196.
ClpP
Related genes: clpP;
Keywords: Stress protein;
Characteristics:
21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes
Functions:
Serine protease involved in proteolysis and is required for growth under stress conditions
References:
Gaillot O, et al., 2000. The ClpP serine protease is essential for the intracellular parasitism and virulence of Listeria monocytogenes. Mol. Microbiol. 35(6):1286-1294.
Gaillot O, et al., 2001. Stress-induced ClpP serine protease of Listeria monocytogenes is essential for induction of listeriolysin O-dependent protective immunity. Infect. Immun. 69(8):4938-4943.
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Bacteria
