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Identified virulence factors of Bordetella: Serum resistance


Brk (Bordetella resistance to killing)  

Related genes: brkA; brkB;
Keywords: Serum resistance;
Characteristics:
The brk locus was also found in B. parapertussis and B. bronchiseptica but not B. avium.
Functions:
Outer membrane protein that mediates adherence and resists complement.
References:
Fernandez RC, Weiss AA, 1994. Cloning and sequencing of a Bordetella pertussis serum resistance locus. Infect. Immun. 62(11):4727-4738.
Barnes MG, Weiss AA, 2001. BrkA protein of Bordetella pertussis inhibits the classical pathway of complement after C1 deposition. Infect. Immun. 69(5):3067-3072.
Oliver DC, et al., 2003. A conserved region within the Bordetella pertussis autotransporter BrkA is necessary for folding of its passenger domain. Mol. Microbiol. 47(5):1367-1383.
Elder KD, et al., 2004. Strain-dependent role of BrkA during Bordetella pertussis infection of the murine respiratory tract. Infect Immun 72(10):5919-24.








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