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Identified virulence factors of Staphylococcus: Antiphagocytosis


Capsule  

Related genes: cap8A; cap8B; cap8C; cap8D; cap8E; cap8F; cap8G; cap8H; cap8I; cap8J; cap8K; cap8L; cap8M; cap8N; cap8O; cap8P;
Keywords: Antiphagocytosis;
Characteristics:
Produced by over 90% of Staphylococcus aureus strains. Two serotypes (5 and 8) predominate among clinical isolates of S. aureus from humans.
Functions:
Prevent phagocytosis.
References:
Thakker M, et al., 1998. Staphylococcus aureus serotype 5 capsular polysaccharide is antiphagocytic and enhances bacterial virulence in a murine bacteremia model. Infect. Immun. 66(11):5183-5189.
Cunnion KM, et al., 2001. Capsule production and growth phase influence binding of complement to Staphylococcus aureus. Infect. Immun. 69(11):6796-6803.
Luong TT, Lee CY, 2002. Overproduction of type 8 capsular polysaccharide augments Staphylococcus aureus virulence. Infect. Immun. 70(7):3389-3395.
Cunnion KM, et al., 2003. Availability of complement bound to Staphylococcus aureus to interact with membrane complement receptors influences efficiency of phagocytosis. Infect. Immun. 71(2):656-662.








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