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Identified Virulence Factors of Legionella : Unclassified


eml loci (early stage macrophage-induced locus)
Functions:
Unknown
References:
Abu Kwaik Y, Pederson LL, 1996. The use of differential display-PCR to isolate and characterize a Legionella pneumophila locus induced during the intracellular infection of macrophages. Mol. Microbiol. 21(3):543-556.


enh loci (enhanced entry)
Related genes: enhA; enhB; enhC;
Functions:
RtxA gene from the enh1 locus seem to be involved in pore formation
References:
Cirillo SL, et al., 2000. Identification of novel loci involved in entry by Legionella pneumophila. Microbiology. 146:1345-1359.


LigA (L. pneumophila infectivity gene)
Related genes: ligA;
Functions:
Protozoa specific gene
Required for replication in protozoa
References:
Fettes PS, et al., 2000. Characterization of the Legionella pneumophila gene ligA. Int. J. Med. Microbiol. 290(3):239-250.


MilA (macrophage infectivity loci A)
Functions:
Important for entry and the reprogramming of the endosomal pathway
References:
Harb OS, Abu Kwaik Y, 2000. Characterization of a macrophage-specific infectivity locus (milA) of Legionella pneumophila. Infect. Immun. 68(1):368-376.


pmi loci (protozoa and macrophage infectivity)
Functions:
Intracellular replication
References:
Gao LY, et al., 1998. Different fates of Legionella pneumophila pmi and mil mutants within macrophages and alveolar epithelial cells. Microb. Pathog. 25(6):291-306.








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