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Identified virulence factors of Legionella: Unclassified


enh loci (enhanced entry)  

Related genes: enhA; enhB; enhC;
Functions:
RtxA gene from the enh1 locus seem to be involved in pore formation.
References:
Cirillo SL, et al., 2000. Identification of novel loci involved in entry by Legionella pneumophila. Microbiology. 146:1345-1359.


LigA (L. pneumophila infectivity gene)  

Related genes: ligA;
Functions:
Protozoa specific gene.
Required for replication in protozoa.
References:
Fettes PS, et al., 2000. Characterization of the Legionella pneumophila gene ligA. Int. J. Med. Microbiol. 290(3):239-250.


pmiA (protozoa and macrophage infectivity loci protein)  

Related genes: pmiA;
Characteristics:
A transmembrane protein with three membrane-spanning regions.
Functions:
A novel virulence factor that is involved in intracellular survival and replication of L. pneumophila in macrophages and protozoan cells.
References:
Miyake M, et al., 2005. Characterization of Legionella pneumophila pmiA, a gene essential for infectivity of protozoa and macrophages. Infect Immun 73(10):6272-82.








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