eml loci
(early stage macrophage-induced locus)
Functions: Unknown
References: Abu Kwaik Y, Pederson LL, 1996. The use of differential display-PCR to isolate and characterize a Legionella pneumophila locus induced during the intracellular infection of macrophages. Mol. Microbiol. 21(3):543-556.
enh loci
(enhanced entry)
Related genes: enhA;
enhB;
enhC;
Functions: RtxA gene from the enh1 locus seem to be involved in pore formation
References: Cirillo SL, et al., 2000. Identification of novel loci involved in entry by Legionella pneumophila. Microbiology. 146:1345-1359.
LigA
(L. pneumophila infectivity gene)
Related genes: ligA;
Functions: Protozoa specific gene
Required for replication in protozoa
References: Fettes PS, et al., 2000. Characterization of the Legionella pneumophila gene ligA. Int. J. Med. Microbiol. 290(3):239-250.
MilA
(macrophage infectivity loci A)
Functions: Important for entry and the reprogramming of the endosomal pathway
References: Harb OS, Abu Kwaik Y, 2000. Characterization of a macrophage-specific infectivity locus (milA) of Legionella pneumophila. Infect. Immun. 68(1):368-376.
pmi loci
(protozoa and macrophage infectivity)
Functions: Intracellular replication
References: Gao LY, et al., 1998. Different fates of Legionella pneumophila pmi and mil mutants within macrophages and alveolar epithelial cells. Microb. Pathog. 25(6):291-306.
|