Identified virulence factors of Legionella: Unclassified
Related genes: enhA;
Functions: RtxA gene from the enh1 locus seem to be involved in pore formation.
References: Cirillo SL, et al., 2000. Identification of novel loci involved in entry by Legionella pneumophila. Microbiology. 146:1345-1359.
(L. pneumophila infectivity gene)
Related genes: ligA;
Functions: Protozoa specific gene.
Required for replication in protozoa.
References: Fettes PS, et al., 2000. Characterization of the Legionella pneumophila gene ligA. Int. J. Med. Microbiol. 290(3):239-250.
(protozoa and macrophage infectivity loci protein)
Related genes: pmiA;
Characteristics: A transmembrane protein with three membrane-spanning regions.
Functions: A novel virulence factor that is involved in intracellular survival and replication of L. pneumophila in macrophages and protozoan cells.
References: Miyake M, et al., 2005. Characterization of Legionella pneumophila pmiA, a gene essential for infectivity of protozoa and macrophages. Infect Immun 73(10):6272-82.