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Identified virulence factors of Legionella: Toxin


RtxA  

Related genes: rtxA;
Keywords: Toxin; Membrane-damaging; Pore-forming toxin;
Functions:
Potent host cell cytolysin, the 'cytolysin/egress pore' is essential for lysis of the host cell from within the phagosome to allow the bacteria to exit.
References:
Cirillo SL, et al., 2001. Legionella pneumophila entry gene rtxA is involved in virulence. Infect. Immun. 69(1):508-517.
D'Auria G, et al., 2008. Virulence factor rtx in Legionella pneumophila, evidence suggesting it is a modular multifunctional protein. BMC Genomics 9:14.








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