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Identified Virulence Factors of Legionella : Stress protein


GspA (global stress gene)
Keywords: Stress protein;
Functions:
19-kDa GroEL-like
Dispensable for bacterial survival and growth in macrophage infection
References:
Abu Kwaik Y, et al., 1997. Transcriptional regulation of the macrophage-induced gene (gspA) of Legionella pneumophila and phenotypic characterization of a null mutant. Mol. Microbiol. 24(3):629-642.


KatAB
Related genes: katA; katB;
Keywords: Stress protein;
Functions:
A periplasmic catalase, expressed maximally during the postexponential phase
Important for intracellular survival and transmission
References:
Bandyopadhyay P, Steinman HM, 1998. Legionella pneumophila catalase-peroxidases: cloning of the katB gene and studies of KatB function. J. Bacteriol. 180(20):5369-5374.
Bandyopadhyay P, Steinman HM, 2000. Catalase-peroxidases of Legionella pneumophila: cloning of the katA gene and studies of KatA function. J. Bacteriol. 182(23):6679-6686.
Bandyopadhyay P, et al., 2003. Legionella pneumophila catalase-peroxidases are required for proper trafficking and growth in primary macrophages. Infect. Immun. 71(8):4526-4535.


SodB
Related genes: sodB;
Keywords: Stress protein;
Functions:
A cytoplasmic iron superoxide dismutase
Important for intracellular survival and transmission
References:
Sadosky AB, et al., 1994. The iron superoxide dismutase of Legionella pneumophila is essential for viability. J. Bacteriol. 176(12):3790-3799.


SodC
Related genes: sodC;
Keywords: Stress protein;
Functions:
A periplasmic copper-zinc superoxide dismutase
Important for intracellular survival and transmission
References:
St John G, Steinman HM, 1996. Periplasmic copper-zinc superoxide dismutase of Legionella pneumophila: role in stationary-phase survival. J. Bacteriol. 178(6):1578-1584.








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