Identified virulence factors of Legionella: Nutrient acquisition
Related genes: phtA;
Keywords: Nutrient acquisition; Transporter; Functions: Enables transmissive L. pneumophila to assess their phagosomal nutrient supply before reentering the cell cycle.
Mechanism: PhtA contains 12 transmembrane domains characteristic of the Major Facilitator Superfamily (MFS) of transporters, was shown to transport threonine, an essential amino acid for L. pneumophila maturation to the replicative phase.
References: Sauer JD, et al., 2005. The phagosomal transporter A couples threonine acquisition to differentiation and replication of Legionella pneumophila in macrophages. Proc. Natl. Acad. Sci. USA. 102(28):9924-9929.