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Identified virulence factors of Legionella: Motility


Flagella  

Related genes: flgA; flgB; flgC; flgD; flgE; flgF; flgG; flgH; flgI; flgK; flgL; flhA; flhB; flhF; fliA; fliC; fliD; fliE; fliF; fliG; fliH; fliJ; fliM; fliN; fliO; fliP; fliQ; fliR; fliS; motB; motC;
Keywords: Motility;
Characteristics:
Flagella expression is associated with the cellular cycle in L. pneumophila, the bacteria are not motile while multiplying in host cells, but become motile in the later stages of the infection process.
Functions:
Not required for intracellular growth but enhance the invasion capacity.
References:
Merriam JJ, et al., 1997. Analysis of the Legionella pneumophila fliI gene: intracellular growth of a defined mutant defective for flagellum biosynthesis. Infect. Immun. 65(6):2497-2501.
Swanson MS, Hammer BK, 2000. Legionella pneumophila pathogesesis: a fateful journey from amoebae to macrophages. Annu. Rev. Microbiol. 54:567-613.
Dietrich C, et al., 2001. Flagellum of Legionella pneumophila positively affects the early phase of infection of eukaryotic host cells. Infect. Immun. 69(4):2116-2122.
Heuner K, Steinert M, 2003. The flagellum of Legionella pneumophila and its link to the expression of the virulent phenotype. Int. J. Med. Microbiol. 293:133-143.








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