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Identified virulence factors of Legionella: Iron uptake


CcmC  

Related genes: ccmC;
Keywords: Iron uptake;
Functions:
Required for cytochrome c production, promotes iron assimilation and intracellular infection.
References:
Viswanathan VK, et al., 2002. The cytochrome c maturation locus of Legionella pneumophila promotes iron assimilation and intracellular infection and contains a strain-specific insertion sequence element. Infect. Immun. 70(4):1842-1852.


FeoAB  

Related genes: feoA; feoB;
Keywords: Iron uptake; Ferrous iron uptake;
Functions:
A feoB mutant of L. pneumophila has a lowered Fe2+ uptake and is attenuated for intracellular growth.
Mechanism:
The FeoB protein is a G protein with properties of GTPase activity kinetics and GTP/GDP binding that differ from those of the eukaryotic proteins. The GTPase activity of FeoB is necessary for Fe2+ transport.
References:
Robey M, Cianciotto NP, 2002. Legionella pneumophila feoAB promotes ferrous iron uptake and intracellular infection. Infect. Immun. 70(10):5659-5669.


FrgA (fur regulated gene)  

Related genes: frgA;
Keywords: Iron uptake; Siderophore;
Characteristics:
Homology with the aerobactin synthesases IucA and IucC.
Functions:
Putative hydroxamate siderophore, iron is critical for L. pneumophila extracellular replication, intracellular infection, and virulence.
References:
Hickey EK, Cianciotto NP, 1997. An iron- and fur-repressed Legionella pneumophila gene that promotes intracellular infection and encodes a protein with similarity to the Escherichia coli aerobactin synthetases. Infect. Immun. 65(1):133-143.


IraAB  

Related genes: iraB;
Keywords: Iron uptake;
Functions:
IraA, a methyltransferase, is critical for virulence.
IraB, a homologue of di- and tri-peptide transporters, may involve in a novel method of iron acquisition which may utilize iron-loaded peptides.
References:
Viswanathan VK, et al., 2000. The Legionella pneumophila iraAB locus is required for iron assimilation, intracellular infection, and virulence. Infect. Immun. 68(3):1069-1079.


Legiobactin  

Related genes: lbtA; lbtB; lbtC; lbtU;
Keywords: Iron uptake; Siderophore;
Functions:
A nonhydroxamate, nonphenolate siderophore.
References:
Liles MR, et al., 2000. Discovery of a nonclassical siderophore, legiobactin, produced by strains of Legionella pneumophila. J. Bacteriol. 182(3):749-757.








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