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Identified virulence factors of Legionella: Endotoxin


LPS  

Related genes: lpg0748; lpg0753; lpg0754; lpg0756; lpg0757; lpg0761; lpg0762; lpg0764; lpg0765; lpg0766; lpg0767; lpg0768; lpg0769; lpg0770; lpg0771; lpg0773; lpg0774; lpg0775; lpg0777; lpg0778; lpg0779; hisF; hisH; neuA; neuB; pgi; rfbA; rfbA; rfbB; yvfE;
Keywords: Endotoxin; Phase variation;
Structure features:
O-side chain is made up of homopolymer repeats of a single sugar residue designated legionaminic acid, and the core region is highly O-acetylated providing hydrophobic characteristic on the LPS structure.
Figures:
Structural representation of the LPS-biosynthesis locus. (From: Petzold M, et al., 2013. A structural comparison of lipopolysaccharide biosynthesis loci of Legionella pneumophila serogroup 1 strains. BMC Microbiol 13:198.)


Functions:
Phase variation associated with changes in virulence.
References:
Luneberg E, et al., 1998. Phase-variable expression of lipopolysaccharide contributes to the virulence of Legionella pneumophila. J. Exp. Med. 188(1):49-60.
Luneberg E, et al., 2001. Chromosomal insertion and excision of a 30 kb unstable genetic element is responsible for phase variation of lipopolysaccharide and other virulence determinants in Legionella pneumophila. Mol. Microbiol. 39(5):1259-1271.








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