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Identified virulence factors of Legionella: Adherence


Hsp60  

Related genes: htpB;
Keywords: Adherence;
Functions:
Mediate a complement-independent attachment to mammalian and amoebal host cells.
Mechanism:
Specific receptors have not been identified.
References:
Garduno RA, et al., 1998. Surface-associated hsp60 chaperonin of Legionella pneumophila mediates invasion in a HeLa cell model. Infect. Immun. 66(10):4602-4610.
Swanson MS, Hammer BK, 2000. Legionella pneumophila pathogesesis: a fateful journey from amoebae to macrophages. Annu. Rev. Microbiol. 54:567-613.


MOMP (major outer membrane protein)  

Related genes: omp28;
Keywords: Adherence;
Functions:
Binds C3 and C3bi of the complement system and mediates the uptake of the bacteria via the CR1 and CR3 receptors of the macrophage.
References:
Hoffman PS, et al., 1992. Cloning and nucleotide sequence of a gene (ompS) encoding the major outer membrane protein of Legionella pneumophila. J. Bacteriol. 174(3):914-920.
Bellinger-Kawahara C, Horwitz MA, 1990. Complement component C3 fixes selectively to the major outer membrane protein (MOMP) of Legionella pneumophila and mediates phagocytosis of liposome-MOMP complexes by human monocytes. J. Exp. Med. 172(4):1201-1210.
Krinos C, et al., 1999. Role of the 25 kDa major outer membrane protein of Legionella pneumophila in attachment to U-937 cells and its potential as a virulence factor for chick embryos. J. Appl. Microbiol. 86(2):237-244.
Swanson MS, Hammer BK, 2000. Legionella pneumophila pathogesesis: a fateful journey from amoebae to macrophages. Annu. Rev. Microbiol. 54:567-613.


Type IV pili  

Related genes: pilB; pilC; pilD;
Keywords: Adherence;
Characteristics:
Also designated as CAP (competence and adherence-associated pili).
Functions:
Contribute to complement-independent binding, perhaps as the ligand for protozoan lectin.
References:
Stone BJ, Abu Kwaik Y, 1998. Expression of multiple pili by Legionella pneumophila: identification and characterization of a type IV pilin gene and its role in adherence to mammalian and protozoan cells. Infect. Immun. 66(4):1768-1775.
Swanson MS, Hammer BK, 2000. Legionella pneumophila pathogesesis: a fateful journey from amoebae to macrophages. Annu. Rev. Microbiol. 54:567-613.
Steinert M, et al., 2002. Legionella pneumophila: an aquatic microbe goes astray. FEMS Microbiol. Rev. 26(2):149-162.








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