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Identified virulence factors of Haemophilus: Immune evasion


P2 protein  

Related genes: ompP2;
Keywords: Immune evasion; Phase variation;
Characteristics:
Most abundant major outer membrane protein of nontypable H. influenzae.
A homotrimeric porin, the surface-exposed loop 6 region is the major epitope against which antibodies are targeted.
Functions:
P2 antigenic drift allows the organism to evade clearance by potentially protective antibodies and contributes to the development of chronic infection.
References:
Sikkema DJ, Murphy TF, 1992. Molecular analysis of the P2 porin protein of nontypeable Haemophilus influenzae. Infect. Immun. 60(12):5204-5211.
Bell J, et al., 1994. Diversity of the P2 protein among nontypeable Haemophilus influenzae isolates. Infect. Immun. 62(6):2639-2643.
Rao VK, et al., 1999. Molecular determinants of the pathogenesis of disease due to non-typable Haemophilus influenzae. FEMS Microbiol. Rev. 23(2):99-129.
Neary JM, et al., 2001. Antibodies to loop 6 of the P2 porin protein of nontypeable Haemophilus influenzae are bactericidal against multiple strains. Infect. Immun. 69(2):773-778.








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