Identified virulence factors of Campylobacter: Secretion system
Type IV secretion system
Related genes: Cjp54;
Keywords: Secretion system; Invasion; Characteristics: C. jejuni pVir is a 37-kb plasmid harboring 54 predicted ORFs, contains genes for homologs of Com and Vir proteins, and shows great similarities to type IV secretion proteins found in cag PAI of H. pylori.
Functions: Plasmid pVir is present only in certain C. jejuni strains, is involved in the microtubule (MT)-dependent invasion pathway.
References: Bacon DJ, et al., 2000. Involvement of a plasmid in virulence of Campylobacter jejuni 81-176. Infect. Immun. 68(8):4384-4390.
Kienesberger S, et al., 2011. Interbacterial macromolecular transfer by the Campylobacter fetus subsp. venerealis type IV secretion system. J. Bacteriol. 193(3):744-758.