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Identified virulence factors of Aeromonas: Adherence


Flp type IV pili  

Related genes: flp1; flpA; flpB; flpC; flpD; flpE; flpF; flpG; flpH; flpI; flpJ; flpK; flpL;
Keywords: Adherence; Type IV pilus; Type IVb pilus;
Characteristics:
Peritrichous.
Resembles the Actinobacillus actinomycetemcomitans Flp pilus.
Functions:
Contributes to biofilm formation and autoagglutination.
References:
Boyd JM, et al., 2008. Contribution of type IV pili to the virulence of Aeromonas salmonicida subsp. salmonicida in Atlantic salmon (Salmo salar L.). Infect Immun 76(4):1445-55.


MSHA type IV pili (mannose-sensitive haemagglutinin type IV pili)  

Related genes: mshA; mshB; mshC; mshD; mshE; mshF; mshG; mshI; mshI1; mshJ; mshK; mshL; mshM; mshN; mshO; mshP; mshQ;
Keywords: Adherence; Type IV pilus;
Characteristics:
Homology to the mannose-sensitive hemagglutinin pilus of Vibrio cholerae.
Functions:
MSHA bundle-forming pilus is the major filamentous appendage responsible for tissue adherence and colonisation.
Essential for biofilm formation.
References:
Hadi N, et al., 2012. Bundle-forming pilus locus of Aeromonas veronii bv. Sobria. Infect Immun 80(4):1351-60.


Tap type IV pili  

Related genes: tapA; tapB; tapC; tapD; tapF; tapM; tapN; tapO; tapP; tapQ; tapT; tapU; tapV; tapW; tapY; tppA; tppB; tppE; tppF;
Keywords: Adherence; Type IV pilus;
Characteristics:
Polar.
Similar to the P. aeruginosa Pil system.
Constitutively expressed.
Functions:
The role of the Tap pilus remains to be elucidated, its biogenesis has strong implications in virulence in other ways. TapD, a prepilin peptidase is not only required for the processing of the prepilins before they are incorporated into the pilus filament but also for the processing of the pseudopilins of the T2SS, that are essential for the secretion of many virulence factors.
References:
Pepe CM, et al., 1996. Cloning of an Aeromonas hydrophila type IV pilus biogenesis gene cluster: complementation of pilus assembly functions and characterization of a type IV leader peptidase/N-methyltransferase required for extracellular protein secretion. Mol Microbiol 19(4):857-69.
Kirov SM, et al., 2000. Investigation of the role of type IV Aeromonas pilus (Tap) in the pathogenesis of Aeromonas gastrointestinal infection. Infect Immun 68(7):4040-8.
Boyd JM, et al., 2008. Contribution of type IV pili to the virulence of Aeromonas salmonicida subsp. salmonicida in Atlantic salmon (Salmo salar L.). Infect Immun 76(4):1445-55.


Type I pili  

Related genes: fimA; fimC; fimD; fimE; fimF;
Keywords: Adherence; Type I pili;
Characteristics:
Short-rigid pili.
Chaperone-usher pathway assembled pili.
Functions:
Involved in the initial stages of colonisation.
References:
Dacanay A, et al., 2010. Aeromonas salmonicida Type I pilus system contributes to host colonization but not invasion. Dis Aquat Organ 88(3):199-206.








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